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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:

34

期数:

2017年10

页码:

940-942

栏目:

临床研究

出版日期:

2017-10-05

文章信息/Info

Title:

Changes of peripheral blood T lymphocyte subsets in the acute stage of Kawasaki disease

作者:

孙秀丽

（商丘市第一人民医院儿科，河南　商丘　476000）

Author(s):

SUN Xiu-li

（Department of Pediatrics，the First People′s Hospital of Shangqiu City，Shangqiu 476000，Henan Province，China）

关键词:

川崎病; 急性期; 外周血T淋巴细胞亚群

Keywords:

Kawasaki disease; acute phase; peripheral blood T lymphocyte subsets

分类号:

R714.252

DOI:

10.7683/xxyxyxb.2017.10.019

文献标志码:

A

摘要:

目的　观察川崎病急性期患儿外周血T淋巴细胞亚群的变化，探讨其可能的免疫机制。方法　选取2014年3月至2015年8月在商丘市第一人民医院接受治疗的46例川崎病急性期患儿为研究组，另选取同期体检健康儿童10例为对照组。采集2组患儿外周血，采用流式细胞术检测T淋巴细胞亚群（CD3⁺、CD4⁺、CD8⁺、CD19⁺、CD4⁺/CD8⁺、CD56⁺CD16⁺）变化情况并进行比较。结果　研究组患儿CD3⁺、CD4⁺、CD8⁺细胞分别为（56.36±4.78）%、（28.14±1.55）%、（21.03±2.36）%，均显著低于对照组的（65.25±5.63）%、（33.12±2.57）%、（28.52±3.12）%（P<0.05）;研究组患儿CD4⁺/CD8⁺、CD19⁺细胞分别为2.51±0.36、（31.85±3.21）%，显著高于对照组的1.51±0.37、（18.61±2.57）%（P<0.05）;研究组患儿CD56⁺CD16⁺细胞与对照组比较差异无统计学意义（P>0.05）。结论　川崎病急性期患儿体内存在免疫紊乱，CD3⁺、CD4⁺、CD8⁺细胞降低与CD4⁺/CD8⁺、CD19⁺细胞上升可能与本病的发生有关。

Abstract:

Objective　To observe the changes of peripheral blood T lymphocyte subsets of children with Kawasaki disease （KD） in acute phase，and to investigate the possible immune mechanism of KD.Methods　Forty-six KD children in acute phase in the First People′s Hospital of Shangqiu City from March 2014 to August 2015 were selected as research group;and 10 healthy children at the same period were selected as control group.The peripheral blood of children in the two groups were collected.The levels of T lymphocyte subsets （CD3⁺，CD4⁺，CD8⁺，CD19⁺，CD4⁺/CD8⁺，CD56⁺CD16⁺） were assessed by flow cytometry and then compared between the two groups.Results　The CD3⁺，CD4⁺，CD8⁺ cells of children in research group were （56.36±4.78）%，（28.14±1.55）%，（21.03±2.36）% respectively，in control group were （65.25±5.63）%，（33.12±2.57）%，（28.52±3.12）% respectively;the CD3⁺，CD4⁺，CD8⁺ cells of children in research group were significantly lower than those in the control group（P<0.05）.The CD4⁺/CD8⁺ ratio and CD19⁺ cell of children in research group were 2.51±0.36，（31.85±3.21）% respectively，in control group were 1.51±0.37，（18.61±2.57）% respectively;the CD4⁺/CD8⁺ ratio and CD19⁺ cell of children in research group were significantly higher than those in the control group （P<0.05）.There was no significant difference in the CD56⁺CD16⁺ cells between research group and control group （P>0.05）.Conclusion　The acute phase KD children exists obvious immunological disorder.The decrease of CD3⁺，CD4⁺，CD8⁺ cells and the increase of CD4⁺/CD8⁺ ratio，CD19⁺ cell may be relate with the occurrence of KD.

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更新日期/Last Update: 2017-10-05