[1]彭　敏,闫　超.瑞舒伐他汀钙对老年慢性心力衰竭患者氧化-抗氧化系统及血管内皮细胞功能的影响[J].新乡医学院学报,2017,34(8):751-754.[doi:10.7683/xxyxyxb.2017.08.024]
　PENG Min,YAN Chao.Effects of rosuvastatin calcium on oxidation-antioxidation system and vascular endothelial cell function in elderly patients with chronic heart failure[J].Journal of Xinxiang Medical University,2017,34(8):751-754.[doi:10.7683/xxyxyxb.2017.08.024]
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瑞舒伐他汀钙对老年慢性心力衰竭患者氧化-抗氧化系统及血管内皮细胞功能的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年8
页码:
751-754
栏目:
临床研究
出版日期:
2017-08-05

文章信息/Info

Title:
Effects of rosuvastatin calcium on oxidation-antioxidation system and vascular endothelial cell function in elderly patients with chronic heart failure
作者:
彭　敏1; 闫　超2
（1.汉中市中心医院药剂科，陕西　汉中　723000；2.西安交通大学第一附属医院心内科，陕西　西安　710061）
Author(s):
PENG Min1; YAN Chao2
（1.Department of Pharmacy，Hanzhong Central Hospital，Hanzhong 723000，Shaanxi Province，China；2.Department of Cardiology，the First Affiliated Hospital of Xi′an Jiaotong University，Xi′an 710061，Shaanxi Province，China）
关键词:
瑞舒伐他汀钙; 慢性心力衰竭; 氧化-抗氧化系统; 血管内皮细胞
Keywords:
rosuvastatin calcium; chronic heart failure; oxidation-antioxidation system; vascular endothelial cell
分类号:
R541.6
DOI:
10.7683/xxyxyxb.2017.08.024
文献标志码:
A
摘要:
目的　观察瑞舒伐他汀钙对老年慢性心力衰竭（CHF）患者氧化-抗氧化系统及血管内皮细胞（VEC）功能的影响。方法　选择2015年6月至2016年5月汉中市中心医院收治的老年CHF患者92例，根据治疗方法分为观察组和对照组，每组46例。对照组患者给予常规治疗，观察组患者在常规治疗基础上给予瑞舒伐他汀钙5 mg，口服，每日1次，连续治疗4周；分别于治疗前及治疗后检测2组患者血清氧化-抗氧化系统指标及VEC功能指标。结果　治疗前，2组患者血清超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-PX）活性和脂质过氧化物（LPO）、丙二醛（MDA）水平比较差异均无统计学意义（P>0.05）。观察组患者治疗后血清SOD、CAT、GSH-PX活性显著高于治疗前（P<0.05），LPO、MDA水平显著低于治疗前（P<0.05）。对照组患者治疗前后血清SOD、CAT、GSH-PX活性和LPO、MDA水平比较差异均无统计学意义（P>0.05）。治疗后，观察组患者血清SOD、CAT、GSH-PX活性显著高于对照组（P<0.05），LPO、MDA水平显著低于对照组（P<0.05）。治疗前2组患者肱动脉流量介导的舒张功能（FMD）及血清一氧化氮（NO）、一氧化氮合酶（NOS）活性、非对称性二甲基精氨酸（ADMA）水平比较差异均无统计学意义（P>0.05）。观察组患者治疗后肱动脉FMD及血清NO、NOS活性显著高于治疗前（P<0.05），血清ADMA水平显著低于治疗前（P<0.05）；对照组患者治疗前后肱动脉FMD及血清NO、NOS活性、ADMA水平比较差异均无统计学意义（P>0.05）。治疗后，观察组患者肱动脉FMD及血清NO、NOS水平显著高于对照组（P<0.05），血清ADMA水平显著低于对照组（P<0.05）。结论　瑞舒伐他汀钙可以显著改善老年CHF患者氧化-抗氧化系统及VEC功能。
Abstract:
Objective　To observe the effect of rosuvastatin calcium on oxidation-antioxidation system and vascular endothelial cell （VEC） function in elderly patients with chronic heart failure （CHF）.Methods　A total of 92 elderly patients with CHF were selected from June 2015 to May 2016 in Hanzhong Central Hospital.The patients were divided into observation group and control group according to the treatment methods，46 cases in each group.The patients in the control group were treated with conventional treatment；based on the conventional treatment，the patients in the observation group were treated with rosuvastatin calcium 5 mg orally，once a day for four weeks.The indexes of serum oxidation-antioxidation system and VEC function were detected before and after treatment in the two groups.Results　There was no significant difference in the levels of serum superoxide dismutase（SOD），catalase（CAT），glutathione peroxidase（GSH-PX），lipid peroxides（LPO） and malondialdehyde（MDA） between the two groups before treatment （P>0.05）.The levels of serum SOD，CAT and GSH-PX after treatment were significantly higher than those before treatment （P<0.05），and the levels of LPO and MDA after treatment were significantly lower than those before treatment in the observation group （P<0.05）.There was no significant difference in the levels of serum SOD，CAT，GSH-PX，LPO and MDA before and after treatment in the control group （P>0.05）.The levels of serum SOD，CAT and GSH-PX in the observation group were significantly higher than those in the control group （P<0.05）；and the levels of LPO and MDA were significantly lower than those in the control group after treatment （P<0.05）.There was no significant difference in brachial artery flow-mediated dilation （FMD） and the levels of serum nitric oxide （NO），nitric oxide synthase （NOS），asymmetric dimethylarginine （ADMA） between the two groups before treatment （P>0.05）.The brachial artery FMD and serum NO，NOS levels after treatment were significantly higher than those before treatment （P<0.05），and the level of ADMA after treatment was significantly lower than that before treatment in the observation group（P<0.05）.There was no significant difference in brachial artery FMD and serum NO，NOS，ADMA levels before and after treatment in the control group （P>0.05）.The brachial artery FMD and serum NO，NOS levels in the observation group were significantly higher than those in the control group （P<0.05），and the level of ADMA in the observation group was significantly lower than that in the control group after treatment （P<0.05）.Conclusion　Rosuvastatin calcium can significantly improve the oxidation-antioxidation system and VEC function in elderly patients with CHF.

参考文献/References:

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更新日期/Last Update: 2017-08-05