[1]马　晓,崔　平,王传升.男性酒精依赖患者戒断早期认知功能及其相关因素分析[J].新乡医学院学报,2017,34(8):723-726.[doi:10.7683/xxyxyxb.2017.08.016]
　MA Xiao,CUI Ping,WANG Chuan-sheng.Cognitive function and its correlation factor in male patients with alcohol dependence during the early abstinent period[J].Journal of Xinxiang Medical University,2017,34(8):723-726.[doi:10.7683/xxyxyxb.2017.08.016]
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男性酒精依赖患者戒断早期认知功能及其相关因素分析
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年8
页码:
723-726
栏目:
临床研究
出版日期:
2017-08-05

文章信息/Info

Title:
Cognitive function and its correlation factor in male patients with alcohol dependence during the early abstinent period
作者:
马　晓; 崔　平; 王传升
（新乡医学院第二附属医院精神五科，河南　新乡　453002）
Author(s):
MA Xiao; CUI Ping; WANG Chuan-sheng
(Department of Psychiatry,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China)
关键词:
酒精依赖; 认知功能; 戒断早期; 相关因素
Keywords:
alcohol dependence; cognitive function; early abstinence; related factors
分类号:
R749.6+2
DOI:
10.7683/xxyxyxb.2017.08.016
文献标志码:
A
摘要:
目的　研究男性酒精依赖患者戒断早期多项认知功能损伤程度同自身饮酒特征之间的关系。方法　以33例戒饮期男性酒精依赖住院患者为酒精依赖组，30名健康男性为对照组，2组受试者分别进行简易精神状况量表（MMSE）、连线测试B（TMT-B）、数字广度测验（DST）、词语流畅性测验（VFT）和霍普金斯词语学习测验修订版（HVLT-R）测评，并对酒精依赖组患者的饮酒特征如开始饮酒年龄、持续饮酒时间、酒精成瘾时间和戒酒次数与认知功能的相关性进行分析。结果　酒精依赖组患者MMSE、DST、VFT和HVLT-R评分分别为28.48±1.42、8.27±1.44、9.79±2.42和21.30±3.60，均显著低于对照组的29.63±0.56、10.53±1.11、12.03±3.67和26.73±2.68（P<0.05）；TMT-B完成时间（133.64±28.68）s，显著长于对照组的（96.47±25.08）s（P<0.05）。酒精依赖组的饮酒特征和认知功能的相关性分析结果显示，酒精依赖组患者的酒精成瘾时间与VFT评分呈负相关（r=-0.388，P<0.05）；戒酒次数与VFT评分呈正相关（r=0.399，P<0.05）；其他一般饮酒特征与各种认知功能之间均无相关性（P>0.05）。结论　戒饮早期男性酒精依赖患者存有明显的认知功能损害，表现为总体认知功能水平降低和执行、注意、语言、记忆能力的下降；酒精依赖患者酒精成瘾时间越长，其认知功能损害越重。
Abstract:
Objective　To investigate the relationship between impairment degree of multiple cognitive function and the characteristics of alcohol consumption in male patients with alcohol dependence during the early abstinent period.Methods　Thirty-three male alcohol dependence patients who at the period of abstinence were selected as alcohol dependence group；thirty healthy men were selected as control group.The cognitive function of all subjects were tested by mini mental sate examination （MMSE），trail making test-B （TMT-B），digit span test （DST），verbal fluency test （VFT） and Hopki verbal learning test-revised （HVLT-R）.The correlation of characteristics of drinking（such as start drinking age，duration of drinking，alcohol addiction time and withdrawal times） with cognitive function was analysed in alcohol dependence group.Results　The scores of MMSE，DST，VFT and HVLT-R of patients in alcohol dependent group was 28.48±1.42，8.27±1.44，9.79±2.42，21.30±3.60 respectively；the above indexes in control group was 29.63±0.56，10.53±1.11，12.03±3.67，26.73±2.68 respectively；the scores of MMSE，DST，VFT and HVLT-R in alcohol dependent group were significantly lower than those in the control group（P<0.05）.The TMT-B completion time of patients in the alcohol dependent group ［（133.64±28.68）s］ was significantly longer than that in the control group［（96.47±25.08）s］（P<0.05）.The correlation analysis results showed that the time of alcohol addiction was negatively correlated with VFT score，and the frequency of alcohol abstinence was positively correlated with VFT score（P<0.05）；other characteristics of drinking were not correlated with cognitive function（P>0.05）.Conclusion　There are a variety of cognitive dysfunction in male alcohol dependence patients during the early abstinent period（such as the overall level of cognitive decline and execution，attention，language，memory function decline）.The longer the time of alcohol addiction，the more severity of cognitive function impairment of patients with alcohol dependence.

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更新日期/Last Update: 2017-08-05