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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:

34

期数:

2017年7

页码:

633-635

栏目:

临床研究

出版日期:

2017-07-05

文章信息/Info

Title:

Effect of minocycline ointment combined with tinidazole in treatment of chronic periapical periodontitis

作者:

王　莉

（河南省省直第二医院口腔科，河南　郑州　450003）

Author(s):

WANG Li

（Department of Stomatology，the Second Hospital of Henan Province，Zhengzhou 450003，Henan Province，China）

关键词:

米诺环素软膏; 替硝唑; 慢性根尖周炎; 肿瘤坏死因子-α; 白细胞介素-1β; 白细胞介素-6

Keywords:

minocycline ointment; tinidazole; chronic periapical periodontitis; tumor necrosis factor-α; interleukin-1β; interleukin-6

分类号:

R781.34

DOI:

10.7683/xxyxyxb.2017.07.021

文献标志码:

A

摘要:

目的　探讨米诺环素软膏联合替硝唑治疗慢性根尖周炎的临床效果。方法　选取2015年4月至2016年9月河南省省直第二医院口腔科108例慢性根尖周炎患者，根据治疗方法分为对照组和观察组，每组54例。对照组患者给予米诺环素软膏治疗，每7 d 1次；观察组患者在对照组治疗基础上给予替硝唑0.25 g，口服，每日1次；2组患者均治疗1个月。检测2组患者治疗前后牙龈指数（GI）、菌斑指数（PLI）、牙齿松动指数（MD）、牙周袋深度（PPD）及牙龈沟液中肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）水平，并比较2组患者治疗总有效率。结果　治疗前2组患者GI、PLI、MD及PPD比较差异均无统计学意义（P>0.05）。治疗后2组患者的GI、PLI、MD及PPD低于治疗前（P<0.05），且观察组患者的GI、PLI、MD及PPD低于对照组（P<0.05）；治疗前2组患者牙龈沟液中TNF-α、IL-1β及IL-6水平比较差异均无统计学意义（P>0.05）；治疗后2组患者牙龈沟液中TNF-α、IL-1β及IL-6水平低于治疗前（P<0.05），且观察组患者牙龈沟液中TNF-α、IL-1β及IL-6水平低于对照组（P<0.05）。观察组和对照组患者治疗总有效率分别为88.89%（48/54）、68.52%（37/54），观察组患者治疗总有效率显著高于对照组（P<0.05）。结论　米诺环素软膏联合替硝唑治疗慢性根尖周炎疗效显著，能降低患者牙龈沟液中TNF-α、IL-1β、IL-6等炎性因子水平，减轻患牙炎症症状。

Abstract:

Objective　To investigate the therapeutic effect of minocycline ointment combined with tinidazole in treatment of chronic periapical periodontitis.Methods　One hundred and eight patients with chronic periapical periodontitis were selected in the Stomatology Department of the Second Hospital of Henan Province from April 2015 to September 2016.The patients were divided into control group and observation group according to different therapeutic method，with 54 cases in each group.Patients in the control group were treated with minocycline ointment，one time every 7 days；the patients in the observation group were given oral treatment of tinidazole 0.25 g on the basis of the treatment of the control group，once a day.The patients in the two groups were treated for one month.The gingival index （GI），plaque index （PLI），mobility of tooth （MD），periodontal pocket depth （PPD） and tumor necrosis factor-alpha（TNF-α），interleukin -1β（IL-1β），interleukin-6（IL-6） levels in gingival crevicular fluid were detected before and after treatment in the two groups，and the total effective rate of the two groups was compared.Results　Before treatment，there was no significant difference in GI，PLI，MD and PPD between the two groups （P> 0.05）.But after treatment，the GI，PLI，MD and PPD in the two groups were lower than those before treatment（P<0.05），and the GI，PLI，MD and PPD in the observation group were lower than those in the control group （P<0.05）.Before treatment，there was no significant difference in the level of TNF-α，IL-1β and IL-6 in gingival sulcus fluid between the two groups（P>0.05）.But after treatment，the levels of TNF-α，IL-1β and IL-6 in gingival sulcus fluid in the two groups were lower than those before treatment（P<0.05），and the levels of TNF-α，IL-1β and IL-6 in gingival sulcus fluid in the observation group were lower than those in the control group （P<0.05）.The total effective rate of the observation group was 88.89% （48/54），and the total effective rate of the control group was 68.52% （37/54），the total effective rate of the observation group was significantly higher than that of the control group （P<0.05）.Conclusion　Minocycline ointment combined with tinidazole is effective in treating chronic periapical periodontitis，which can reduce the level of TNF-α，IL-1β and IL-6 in gingival sulcus fluid and relieve the risk of tooth inflammation.

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更新日期/Last Update: 2017-07-05