[1]张　强,牛吉攀.化学治疗联合复方苦参注射液治疗晚期胃癌疗效观察[J].新乡医学院学报,2017,34(6):507-509.[doi:10.7683/xxyxyxb.2017.06.014]
　ZHANG Qiang,NIU Ji-pan.Effect of chemotherapy combined with compound matrine injection for treatment of advanced gastric cancer[J].Journal of Xinxiang Medical University,2017,34(6):507-509.[doi:10.7683/xxyxyxb.2017.06.014]
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化学治疗联合复方苦参注射液治疗晚期胃癌疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年6
页码:
507-509
栏目:
临床研究
出版日期:
2017-06-05

文章信息/Info

Title:
Effect of chemotherapy combined with compound matrine injection for treatment of advanced gastric cancer
作者:
张　强; 牛吉攀
（河南省省直第二医院内科，河南　郑州　450003）
Author(s):
ZHANG Qiang; NIU Ji-pan
（Department of Internal Medicine，the Second Provincial Hospital of Henan Province，Zhengzhou 450003，Henan Province，China）
关键词:
晚期胃癌; 化学治疗; 复方苦参注射液
Keywords:
advanced gastric cancer; chemotherapy; compound matrine injection
分类号:
R735.2
DOI:
10.7683/xxyxyxb.2017.06.014
文献标志码:
A
摘要:
目的　探讨化学治疗联合复方苦参注射液治疗晚期胃癌的临床效果。方法　选取河南省省直第二医院2015年3月至2016年5月收治的晚期胃癌患者60例作为研究对象，将患者分为观察组和对照组，每组30例。对照组患者给予FOLFIRI方案（伊立替康+氟尿嘧啶+亚叶酸钙）治疗；观察组患者给予复方苦参注射液联合FOLFIRI方案治疗；14 d为1个疗程，治疗4个疗程后比较2组患者的临床疗效及不良反应。结果　对照组患者治疗后完全缓解3例，部分缓解13例，疾病稳定10例，疾病进展4例；观察组患者治疗后完全缓解4例，部分缓解13例，疾病稳定8例，疾病进展5例。观察组和对照组患者治疗有效率分别为56.7%（17/30）和53.3%（16/30），2组患者治疗有效率比较差异无统计学意义（χ2=0.317，P>0.05）。观察组患者生物化学指标异常、周围神经毒性、食欲缺乏、恶性呕吐发生率低于对照组（P<0.05），但2组患者脱发发生率比较差异无统计学意义（P>0.05）。结论　复方苦参注射液联合FOLFIRI方案治疗晚期胃癌可加强抗肿瘤作用，减少化学治疗过程中的不良反应。
Abstract:
Objective　To evaluate the clinical efficacy of chemotherapy combined with compound matrine injection for treatment of advanced gastric cancer.Methods　Sixty advanced gastric cancer patients in the Second Provincial Hospital of Henna Province from March 2015 to May 2016 were selected and divided into the observation group（n=30） and the control group（n=30）.The patients in the control group were given FOLFIRI regimen （irinotecan+ fluorouracil +calcium folinate） chemotherapy；the patients in the observation group were given FOLFIRI regimen chemotherapy combined with compound matrine injection.Fourteen days was a course of treatment.After four courses of treatment，the clinical efficacy and the incidence of adverse reactions were compared between the two groups.Results　In the control group，3 patients were complete remission（CR），13 patients were partial remission（PR），10 patients were stabile disease （SD），4 patients were progressive disease （PD）；in the observation group，4 patients were CR，13 patients were PR，8 patients were SD，5 patients were PD.The effective rate in the control group and observation group was 53.3%(17/30) and 56.7%(16/30) respectively；there was no statistic difference in the effective rate between the two groups（χ2=0.317，P>0.05）.The incidences of abnormal biochemistry indexes，peripheral nerve toxicity，loss of appetite，nausea and vomiting were significantly lower than those in the control group（P<0.05）；there was no statistic difference in the incidence of baldness between the two groups（P>0.05）.Conclusion　The FOLFIRI regimen combined with compound matrine injection for treatment of advanced gastric cancer can enhance the effect of anti-tumor and reduce the adverse reactions.

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更新日期/Last Update: 2017-06-05