[1]岳浩迪,朱小飞.Sirtuin 1对免疫细胞调节效应及机制研究进展[J].新乡医学院学报,2017,34(6):455-459.[doi:10.7683/xxyxyxb.2017.06.001]
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Sirtuin 1对免疫细胞调节效应及机制研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年6
页码:
455-459
栏目:
国家自然科学基金专题述评
出版日期:
2017-06-05

文章信息/Info

作者:
岳浩迪1; 朱小飞1; 2
（1.新乡医学院医学检验学院，河南　新乡　453003；2.新乡医学院分子诊断与医学检验技术河南省协同创新中心，河南　新乡　453003）
关键词:
Sirtuin 1; 去乙酰化; 巨噬细胞; 树突状细胞; T细胞; 免疫调节
分类号:
R392
DOI:
10.7683/xxyxyxb.2017.06.001
文献标志码:
A
摘要:
免疫细胞（巨噬细胞、树突状细胞、淋巴细胞等）是免疫应答的重要参与者，是机体免疫系统免疫防御、免疫监视及免疫自稳体现的重要实施者。当机体对免疫细胞功能的正常调节出现失常，往往易导致各种疾病（自身免疫性疾病、感染性疾病、肿瘤及心血管疾病等）的发生和发展。Sirtuin 1是具有烟酰胺腺嘌呤二核苷酸依赖性的第3类组蛋白去乙酰化酶家族成员，是细胞寿命与代谢等生理活动中重要的转录调控因子，广泛参与癌症、神经退行性病变和代谢性疾病等老年性疾病的病理发展过程。近年来，Sirtuin 1在免疫细胞功能调控方面的研究逐渐获得关注，本文就此方面研究进展进行述评。

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更新日期/Last Update: 2017-06-05