[1]唐　钊,吴春磊,侯国栋,等.马栗种子提取物治疗ⅢB型前列腺炎疗效观察[J].新乡医学院学报,2017,34(5):398-401.[doi:10.7683/xxyxyxb.2017.05.013]
　TANG Zhao,WU Chun-lei,HOU Guo-dong,et al.Curative effect of the extract of horse chestnut seeds for treatment of ⅢB prostatitis[J].Journal of Xinxiang Medical University,2017,34(5):398-401.[doi:10.7683/xxyxyxb.2017.05.013]
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马栗种子提取物治疗ⅢB型前列腺炎疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年5
页码:
398-401
栏目:
临床研究
出版日期:
2017-05-05

文章信息/Info

Title:
Curative effect of the extract of horse chestnut seeds for treatment of ⅢB prostatitis
作者:
唐　钊; 吴春磊; 侯国栋; 席玉杭; 余沁楠; 朱　峰; 张会清
（新乡医学院第一附属医院泌尿外科，河南　卫辉　453100）
Author(s):
TANG Zhao; WU Chun-lei; HOU Guo-dong; XI Yu-hang; YU Qin-nan; ZHU Feng; ZHANG Hui-qing
（Department of Urinary Surgery，the First Affiliated Hospital of Xinxiang Medical University，Weihui 453100，Henan Province，China）
关键词:
马栗种子提取物; 盐酸坦索罗辛缓释胶囊; 前列舒通胶囊; 前列腺炎
Keywords:
extract of horse chestnut seeds; tamsulsosin hydrochloride capsules; Qianlie Shutong capsules; prostatitis
分类号:
R697+.33
DOI:
10.7683/xxyxyxb.2017.05.013
文献标志码:
A
摘要:
目的　探讨马栗种子提取物治疗ⅢB型前列腺炎的临床效果。方法　选取2015年8月至2016年6月新乡医学院第一附属医院收治的ⅢB型前列腺炎患者81例，按治疗方法将患者分为观察组（n=40）和对照组（n=41）。对照组患者给予盐酸坦索罗辛缓释胶囊和前列舒通胶囊治疗，观察组患者给予马栗种子提取物、盐酸坦索罗辛缓释胶囊和前列舒通胶囊治疗。观察2组患者用药4周后的临床治疗效果，并观察2组患者治疗前后前列腺炎症状指数（NIH-CPSI）评分及前列腺液（EPS）中白细胞计数（WBC）、白细胞介素-8（IL-8）及肿瘤坏死因子-α（TNF-α）水平的变化。结果　治疗过程中对照组脱落4例（2例中断服药，2例未按时复诊），观察组脱落6例（3例拒绝按治疗方案服药，1例中断服药，2例未按时复诊），最终对照组纳入病例37例，观察组纳入病例34例。用药4周后，对照组37例患者中，临床治愈2例（5.40%），显效4例（10.81%），有效19例（51.35%），无效12例（32.43%）；观察组34例患者中，临床治愈3例（8.82%），显效14例（41.18%），有效14例（41.18%），无效3例（8.82%）；观察组患者的临床疗效显著优于对照组（P<0.05）。2组患者均未发生不良反应。2组患者治疗前NIH-CPSI评分、EPS-WBC及EPS中的IL-8、TNF-α水平比较差异均无统计学意义（P>0.05）；2组患者治疗后的EPS-WBC与治疗前比较差异均无统计学意义（P>0.05），NIH-CPSI评分及EPS中的IL-8、TNF-α水平均显著低于治疗前（P<0.05）；治疗后，观察组患者的EPS-WBC与对照组比较差异无统计学意义（P>0.05），NIH-CPSI评分及EPS 中的IL-8、TNF-α水平与对照组比较显著降低（P<0.05）。结论　马栗种子提取物治疗ⅢB型前列腺炎可显著降低EPS中炎性因子水平，具有良好的临床效果，且不良反应少，可以作为此类患者的辅助用药。
Abstract:
Objective　To investigate the curative effect of the extract of horse chestnut seeds for treatment of ⅢB prostatitis.Methods　A total of 81 patients with ⅢB prostatitis were selected from August 2015 and June 2016 in the First Affiliated Hospital of Xinxiang Medical University.The patients were divided into control group（n=41）and observation group（n=40）according to the treatment method.The patients in the control group were treated with tamsulosin hydrochloride sustained release capsules and Qianlie Shutong capsules，while the patients in the observation group were treated with extract of horse chestnut seeds，tamsulosin hydrochloride sustained release capsules and Qianlie Shutong capsules.The treatment effect was observed after treatment for 4 weeks.The National Institutes of Health-chronic prostatitis symptom index（NIH-CPSI）score and the levels of interleukin-8（IL-8），tumor necrosis factor-α（TNF-α）in liquor prostaticus were detected before and after treatment in the two groups.Results　During the course of treatment，4 cases（2 cases discontinued medication，2 cases did not return visit on time）in the control group and 6 cases（3 cases refused to take medication according to the treatment plan，1 case discontinued medication，and the other 2 cases failed to return visit on time）in the observation group withdrew.Thirty-seven cases in control group and thirty-four cases in observation group were enrolled finally.Four weeks after treatment，the results of the 37 cases in the control group were clinical cure in 2 cases（5.40%），markedly effective in 4 cases（10.81%），effective in 19 cases（51.35%）and ineffective in 12 cases（32.43%）；the results of the 34 cases in the observation group were clinical cure in 3 cases（8.82%），markedly effective in 14 cases（41.18%），effective in 14 cases（41.18%）and ineffective in 3 cases（8.82%）.The clinical effect in the observation group was significantly better than that in the control group（P<0.05）.There was no adverse reaction in the two groups.There was no significant difference in the NIH-CPSI score，EPS-WBC and the levels of IL-8，TNF-α in EPS between the two groups before treatment（P>0.05）.There was no significant difference in EPS-WBC before and after treatment in the two groups（P>0.05）.The NIH-CPSI score and the levels of IL-8 and TNF-α in EPS after treatment were significantly lower than those before treatment in the two groups（P<0.05）.There was no significant difference in EPS-WBC between the two groups after treatment（P>0.05）.The NIH-CPSI score and the levels of IL-8，TNF-α in EPS of patients in the observation group were significantly lower than those in the control group after treatment（P<0.05）.Conclusion　Combined extract of horse chestnut seeds can significantly reduce the inflammatory factors in EPS of patients with ⅢB prostatitis，which has good clinical effect and less adverse reactions.It can be used as adjuvant therapy for ⅢB prostatitis patients.

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更新日期/Last Update: 2017-05-05