[1]周　博,杨言通,王公平,等.前哨淋巴结导航技术在老年早期胃窦部腺癌手术中的应用价值[J].新乡医学院学报,2017,34(4):316-319.[doi:10.7683/xxyxyxb.2017.04.019]
　ZHOU Bo,YANG Yan-tong,WANG Gong-ping,et al.Value of sentinel lymph node navigation in the operation of elderly patients with early gastric antral adenocarcinoma[J].Journal of Xinxiang Medical University,2017,34(4):316-319.[doi:10.7683/xxyxyxb.2017.04.019]
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前哨淋巴结导航技术在老年早期胃窦部腺癌手术中的应用价值
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年4
页码:
316-319
栏目:
临床研究
出版日期:
2017-04-05

文章信息/Info

Title:
Value of sentinel lymph node navigation in the operation of elderly patients with early gastric antral adenocarcinoma
作者:
周　博; 杨言通; 王公平; 陈　晔; 冯笑山
（河南科技大学临床医学院　河南科技大学第一附属医院胃肠肿瘤外科，河南　洛阳　471003）
Author(s):
ZHOU Bo; YANG Yan-tong; WANG Gong-ping; CHEN Ye; FENG Xiao-shan
（Department of Gastrointestinal Oncological Surgery,the First Affiliated Hospital of Henan University of Science and Technology;Clinical Medical College of Henan University of Science and Technology,Luoyang 471003,Henan Province,China)
关键词:
前哨淋巴结; 胃癌; 专利蓝; 胃大部切除术
Keywords:
sentinel lymph node; gastric carcinoma; patent blue; subtotal gastrectomy
分类号:
R735.2
DOI:
10.7683/xxyxyxb.2017.04.019
文献标志码:
A
摘要:
目的　探讨老年早期胃窦部腺癌患者手术中采用专利蓝示踪前哨淋巴结（SLN）预测胃周淋巴结转移状态的临床价值。方法　选择2014年6月至2016年6月河南科技大学第一附属医院收治的老年早期胃窦部腺癌患者48例，所有患者行远端胃大部切除术，手术时，先将专利蓝液（1∶1稀释）注射于肿瘤周围浆膜下，找到最先染色的胃周SLN，然后行D2根治术，术后将SLN及其余各组淋巴结进行病理检查，评估胃周淋巴结转移状态。结果　48例患者中，46例患者通过术中专利蓝示踪检出SLN，检出率为95.8%（46/48）。应用专利蓝示踪SLN状态来预测老年早期胃窦部腺癌患者胃周淋巴结转移的准确性为91.3%（42/46），敏感性为80.0％（16/20），特异性为100.0%（26/26），假阴性率为11.1%（2/18）。SLN转移阳性率、检出率、准确性、敏感性及假阴性率与患者性别无显著相关性（P>0.05）；SLN转移阳性率与肿瘤浸润深度有显著相关性（P<0.01），而SLN检出率、准确性、敏感性及假阴性率与肿瘤浸润深度无显著相关性（P>0.05）。结论　老年早期胃癌患者手术时使用专利蓝进行SLN示踪可以较为准确地判断胃周淋巴结转移情况。
Abstract:
Objective　To investigate the clinical value of patent blue tracing sentinel lymph node （SLN) in predicting the lymph node metastasis in elderly patients with early gastric antral adenocarcinoma.Methods　Forty-eight patients with early early gastric antral adenocarcinoma who underwent distal subtotal gastrectomy in the First Affiliated Hospital of Henan University of Science and Technology from June 2014 to June 2016 were selected.During the operation,the patent blue liquid （1∶1 dilution) was injected into the serous membrane around the tumor to find the stained gastric SLN,and then the D2 radical operation was performed.The SLN and other lymph nodes were performed with pathological examination to evaluate the status of lymph node metastasis.Results　In the 48 cases,SLN was detected by intraoperative patent blue tracer in 46 patients,the detection rate of SLN was 95.8%（46/48).The accuracy,sensitivity,specificity and false negative rate of patent blue tracing SLN to predict the lymph node metastasis in elderly patients with early gastric adenocarcinoma was 91.3% （42/46),80.0％（16/20),100.0%（26/26) and 11.1%（2/18) respectively.The SLN metastasis positive rate,detection rate,accuracy,sensitivity and false negative rate were unrelated to the gender of the patients （P>0.05).The SLN metastasis positive rate was significantly correlated with the tumor invasion （P<0.01);but the detection rate,accuracy,sensitivity and false negative rate were unrelated to the tumor invasion（P>0.05).Conclusion　Using patent blue to track SLN can accurately evaluate the status of perigastric lymph node metastasis in the operation of the elderly patients with early gastric antral adenocarcinoma.

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更新日期/Last Update: 2017-04-05