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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:

34

期数:

2017年3

页码:

173-176

栏目:

基础研究

出版日期:

2017-03-05

文章信息/Info

Title:

Expression of human metaherin，carcinoembryonic antigen related cell adhesion molecule 1 and hepatitis B virus X protein in hepatitis B virus related hepatocellular carcinoma

作者:

陶鹏辉

（信阳市中心医院检验科，河南　信阳　464000）

Author(s):

TAO Peng-hui

（Department of Clinical Laboratory，the Central Hospital of Xinyang City，Xinyang 464000，Henan Province，China）

关键词:

乙型肝炎相关性肝癌; 人异黏蛋白; 癌胚抗原相关细胞黏附分子1; 乙型肝炎病毒X蛋白

Keywords:

hepatitis B virus related hepatocellular carcinoma; metaherin; carcinoembryonic antigen related cell adhesion molecule 1; hepatitis B virus X protein

分类号:

R735.7

DOI:

10.7683/xxyxyxb.2017.03.004

文献标志码:

A

摘要:

目的　探讨乙型肝炎相关性肝癌（HCC）组织中人异黏蛋白（MTDH）、癌胚抗原相关细胞黏附分子1（CEACAM1）、乙型肝炎病毒X蛋白（HBx）的表达及临床意义。方法　选取2014年3月至2016年3月信阳市中心医院保存的乙型肝炎相关性HCC组织标本58例及相应的癌旁组织标本23例，采用免疫组织化学方法检测HCC组织和癌旁组织中MTDH、CEACAM1、HBx表达，并分析三者与乙型肝炎相关性HCC临床病理特征的关系。结果　HCC组织和癌旁组织中MTDH阳性表达率分别为62.07%（36/58）、30.43%（7/23），HCC组织中MTDH阳性表达率显著高于癌旁组织（P<0.05）。HCC组织和癌旁组织中CEACAM1阳性表达率分别为43.10%（25/58）、69.57%（16/23），HCC组织中CEACAM1阳性表达率显著低于癌旁组织（P<0.05）。HCC组织和癌旁组织中HBx阳性表达率分别为79.31%（46/58）、43.48%（10/23），HCC组织中HBx阳性表达率显著高于癌旁组织（P<0.01）。MTDH和CEACAM1在乙型肝炎相关性HCC组织中的表达与患者的年龄、性别无相关性（P>0.05），但与肿瘤直径、TNM分期、门静脉侵袭、淋巴结转移及分化程度有相关性（P<0.05）。HBx在乙型肝炎相关性HCC组织中的表达与患者年龄、性别、肿瘤直径无相关性（P>0.05），但与TNM分期、门静脉侵袭、淋巴结转移及分化程度有相关性（P<0.05）。乙型肝炎相关性HCC组织中MTDH表达与CEACAM1、HBx表达无显著相关性（r=-0.169、0.124，P>0.05），CEACAM1与HBx表达呈负相关（r=-0.316，P<0.05）。结论　乙型肝炎相关性HCC组织中MTDH和HBx表达上调，CEACAM1表达下调；MTDH、CEACAM1和HBx表达与乙型肝炎相关性HCC的发生、发展有关。

Abstract:

Objective　To investigate the clinical significance of the expression of human metaherin（MTDH），carcinoembryonic antigen related cell adhesion molecule 1（CEACAM1） and hepatitis B virus X protein（HBx） in hepatitis B virus related hepatocellular carcinoma（HCC）.Methods　A total of 58 cases of hepatitis B virus related HCC tissue specimens and 23 cases of paraneoplastic tissue specimens were selected in the Central Hospital of Xinyang City from March 2014 to March 2016.The expression of MTDH，CEACAM1，HBx in HCC tissues and paraneoplastic tissues was detected by immunohistochemical method.The relationship between the three indexes and the clinicopathological features of hepatitis B virus related HCC was analyzed.Results　The positive expression rate of MTDH in HCC and paraneoplastic tissues was 62.07%（36/58） and 30.43%（7/23），respectively；the positive expression rate of MTDH in HCC tissues was significantly higher than that in paraneoplastic tissues （P<0.05）.The positive expression rate of CEACAM1 in HCC and paraneoplastic tissues was 43.10%（25/58） and 69.57%（16/23），respectively；the positive expression rate of CEACAM1 in HCC tissues was significantly lower than that in paraneoplastic tissues （P<0.05）.The positive expression rate of HBx in HCC and paraneoplastic tissues was 79.31%（46/58） and 43.48%（10/23），respectively；the positive expression rate of HBx in HCC tissues was significantly higher than that in paraneoplastic tissues （P<0.05）.The expression of MTDH and CEACAM1 in hepatitis B virus related HCC was not correlated with the age and gender of the patients （P>0.05）；but it was correlated with the diameter of tumor，TNM staging，portal vein invasion，lymph node metastasis and differentiation （P<0.05）.The expression of HBx in hepatitis B virus related HCC was not correlated with the diameter of tumor，the age and gender of the patients （P>0.05）；but it was correlated with the TNM staging，portal vein invasion，lymph node metastasis and differentiation （P<0.05）.There was no significant correlation between the expression of MTDH and CEACAM1，HBx in hepatitis B virus associated HCC（r=-0.169，0.124；P>0.05）.The expression of CEACAM1 was negatively correlated with the expression of HBx（r=-0.316，P<0.05）.Conclusion　The expression of MTDH and HBx in hepatitis B virus related HCC tissues is up-regulated，and the expression of CEACAM1 is down-regulated.The expression of MTDH，CEACAM1 and HBx is related to the occurrence and development of hepatitis B virus related HCC.

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更新日期/Last Update: 2017-03-05