[1]马　骏,孙梦夕,张　琳,等.首发精神分裂症患者治疗效果与血清炎性因子水平变化关系研究[J].新乡医学院学报,2017,34(2):113-116.[doi:10.7683/xxyxyxb.2017.02.009]
　MA Jun,SUN Meng-xi,ZHANG Lin,et al.Correlation of the levels of serum inflammatory factors in first-episode schizophrenia patients with the therapeutic effects[J].Journal of Xinxiang Medical University,2017,34(2):113-116.[doi:10.7683/xxyxyxb.2017.02.009]
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首发精神分裂症患者治疗效果与血清炎性因子水平变化关系研究
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年2
页码:
113-116
栏目:
临床研究
出版日期:
2017-02-05

文章信息/Info

Title:
Correlation of the levels of serum inflammatory factors in first-episode schizophrenia patients with the therapeutic effects
作者:
马　骏1; 孙梦夕1; 张　琳1; 杨勇锋1; 张　燕1; 张　岱2; 吕路线1
（1.新乡医学院第二附属医院精神科　河南省生物精神病学重点实验室，河南　新乡　453002；2.北京大学第六医院精神科，北京　100191）
Author(s):
MA Jun1; SUN Meng-xi1; ZHANG Lin1; YANG Yong-feng1; ZHANG Yan1; ZHANG Dai2; LYU Lu-xian1
(1.Department of Psychiatry，the Second Affiliated Hospital of Xinxiang Medical University；Henan Key Lab of Biological Psychiatry，Xinxiang 453002，Henan Province，China；2.Department of Psychiatry，the Sixth Hospital of Peking University，Beijing 100191，China)
关键词:
精神分裂症; 超敏C-反应蛋白; 白细胞介素-1β; 白细胞介素-6; 白细胞介素-17; 转化生长因子-β1
Keywords:
schizophrenia; high sensitivity C-reactive protein; interleukin-1β; interleukin-6; interleukin-17; transforming growth factor-β1
分类号:
R749.3
DOI:
10.7683/xxyxyxb.2017.02.009
文献标志码:
A
摘要:
目的　研究首发精神分裂症患者治疗效果与血清炎性因子水平变化的关系。方法　选取2015年2月至2016年10月在新乡医学院第二附属医院住院的82例首发男性精神分裂症患者，所有患者在入院当天及给予奥氮平治疗4周后评测阳性和阴性症状量表（PANSS）得分，同时测定血清炎性因子超敏C-反应蛋白（hs-CRP）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、白细胞介素-17（IL-17）和转化生长因子-β1（TGF-β1）水平。根据奥氮平治疗前后PANSS减分率将患者分为A组（减分率<50%）和B组（减分率≥50%），并比较2组患者治疗前后hs-CRP、IL-1β、IL-6、IL-17和TGF-β1水平变化。结果　82例患者治疗前PANSS评分为88.34±11.50，治疗4周后降为67.15±18.69，平均减分率（38.84±25.33）%；其中有42例（51.22%）PANSS减分率<50%（A组），40例（48.78%）PANSS减分率≥50%（B组）。与治疗前比较，奥氮平治疗4周后，82例患者hs-CRP水平显著升高（P<0.05），IL-1β、IL-6、IL-17水平显著降低（P<0.05），TGF-β1水平无明显变化（P>0.05）。治疗4周后，2组患者血清hs-CRP水平均较治疗前显著升高（P<0.05），IL-1β、IL-6和IL-17水平显著降低（P<0.05）；与B组相比，A组患者血清IL-1β、IL-6、IL-17水平显著下降（P<0.05）。结论　血清IL-1β、IL-6、IL-17水平在一定程度上可以反映治疗效果，可作为评估患者预后的潜在性生物学指标。
Abstract:
Objective　To study the correlation between the levels of serum inflammatory factors in first-episode schizophrenia patients and the therapeutic effects.Methods　Eighty-two male patients with first schizophrenia were selected in the Second Affiliated Hospital of Xinxiang Medical University from February 2015 to October 2016.The positive and negative symptom scale (PANSS) scores of patients were determined on admission and after 4 weeks of treatment with olanzapine.At the same time，the serum levels of inflammatory factors of high sensitivity C-reactive protein (hs-CRP)，interleukin-1 beta (IL-1β)，interleukin-6 (IL-6)，interleukin-17 (IL-17) and transforming growth factor-β1 (TGF-β1) were determined in the patients.According to the reduced rate of PANSS before and after treatment with olanzapine，the patients were divided into group A (reduced rate <50%) and group B (reduced rate≥50%).The levels of hs-CRP，IL-1β，IL-6，IL-17 and TGF-β1 of patients were compared between the two groups before and after treatment.Results　The PANSS score of 82 patients was 88.34±11.50 and 67.15±18.69 before and after treatment，the average reduction rate was (38.84±25.33)%.PANSS reduction rate was less than 50% in 42 patients(51.22%) (group A)，greater than or equal to 50% in 40 patients(48.78%) (group B).The hs-CRP levels of all patients after treatment were significantly higher than before treatment (P<0.05)，while the IL-1β，IL-6 and IL-17 levels were significantly lower than before treatment(P<0.05)；and there were no significant difference in the levels of TGF-β1 of all patients before and after treatment (P<0.05).The hs-CRP levels of patients after treatment were significantly higher than before treatment in the two groups(P<0.05)，while the IL-1β，IL-6 and IL-17 levels were significantly lower than before treatment(P<0.05).After 4 weeks treatment，the serum levels of IL-1β，IL-6 and IL-17 of the patients in group A were significantly lower than those in group B (P<0.05).Conclusion　Serum levels of IL-1β，IL-6 and IL-17 can reflect the therapeutic effect in a certain extent；they can be used as a potential biological marker for evaluating the prognosis of the patients.

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更新日期/Last Update: 2017-02-05