[1]袁　琳,韩光亮.MiR-155在动脉粥样硬化发生发展中的作用研究进展[J].新乡医学院学报,2016,33(10):930-933.[doi:10.7683/xxyxyxb.2016.10.026]
　YUAN Lin,HAN Guangliang.Research progress on the role of miR-155 in the occurrence and development of atherosclerosis[J].Journal of Xinxiang Medical University,2016,33(10):930-933.[doi:10.7683/xxyxyxb.2016.10.026]
点击复制

MiR-155在动脉粥样硬化发生发展中的作用研究进展
分享到：

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年10
页码:
930-933
栏目:
综述
出版日期:
2016-10-05

文章信息/Info

Title:
Research progress on the role of miR-155 in the occurrence and development of atherosclerosis
作者:
袁　琳; 韩光亮
（新乡医学院公共卫生学院，河南　新乡　453003）
Author(s):
YUAN Lin; HAN Guangliang
关键词:
miR-155; 动脉粥样硬化; 细胞; 心血管疾病
分类号:
R543.3
DOI:
10.7683/xxyxyxb.2016.10.026
文献标志码:
A
摘要:
动脉粥样硬化（AS）是一种多基因、多因素介导的慢性炎性心血管疾病。MiRNAs是长约22个核苷酸的非编码RNA，通过转录后水平的表达，在感染和心血管疾病的生理病理中发挥重要作用。MiR-155是典型的多功能miRNA，其介导的调节广泛参与了AS的内皮细胞、巨噬细胞、树突状细胞、血管平滑肌细胞和白细胞亚群的分化。在体外miR-155调节基因与不同炎症细胞类型的相关表达，也可影响体内AS进程。本文就miR-155在AS进程中的作用和机制作一综述，探讨其在AS诊断和治疗中的作用。

参考文献/References:

［1］　ILHAN F,KALKANLI S T.Atherosclerosis and the role of immune cells［J］.World J Clin Cases,2015,3(4):345.
［2］　KASSITERIDI C,MONACO C.Macrophages and dendritic cells:the usual suspects in atherogenesis［J］.Curr Drug Targets,2015,16(4):373-382.
［3］　DAS S,HALUSHKA M K.Extracellular vesicle microRNA transfer in cardiovascular disease［J］.Cardiovasc Pathol,2015，24(4):199-206.
［4］　CAKMAK H A,COSKUNPINAR E,IKITIMUR B,et al.The prognostic value of circulating microRNAs in heart failure:preliminary results from a genome-wide expression study［J］.J Cardiovasc Med,2015,16(6):431-437.
［5］　REINHART B J,SLACK F J,BASSON M,et al.The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans［J］.Nature,2000,403(6772):901-906.
［6］　SEOK H Y,CHEN J,KATAOKA M,et al.Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy［J］.Circ Res,2014,114(10):1585-1595.
［7］　RAYNER K J.MicroRNA-155 in the heart the right time at the right place in the right cell［J］.Circulation,2015,131(18):1533-1535.
［8］　SEOK H Y,TATSUGUCHI M,CALLIS T E,et al.miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation［J］.J Biol Chem,2011,286(41):35339-35346.
［9］　MURDOCH C E,CHAUBEY S,ZENG L,et al.Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through proinflammatory effects and endothelial-mesenchymal transition［J］.J Am Coll Cardiol,2014,63(24):2734-2741.
［10］　ZHU N,ZHANG D,CHEN S,et al.Endothelial enriched microRNAs regulate angiotensin Ⅱ-induced endothelial inflammation and migration［J］.Atherosclerosis,2011,215(2):286-293.
［11］　MARTIN M M,LEE E J,BUCKENBERGER J A,et al.MicroRNA-155 regulates human angiotensin Ⅱ type 1 receptor expression in fibroblasts［J］.J Biol Chem,2013,288(6):4226.
［12］　PANKRATZ F,BEMTGEN X,ZEISER R,et al.MicroRNA-155 exerts cell-specific antiangiogenic but proarteriogenic effects during adaptive neovascularization［J］.Circulation,2015,131(18):1575-1589.
［13］　HANSSON G K.Inflammation,atherosclerosis,and coronary artery disease［J］.N Engl J Med,2005,352(16):1685-1695.
［14］　SUN H X,ZENG D Y,LI R T,et al.Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase［J］.Hypertension,2012,60(6):1407-1414.
［15］　WEBER M,KIM S,PATTERSON N,et al.MiRNA-155 targets myosin light chain kinase and modulates actin cytoskeleton organization in endothelial cells［J］.Am J Physiol Heart Circ Physiol,2014,306(8):H1192-H1203.
［16］　WANG L,SHAH P K,WANG W,et al.Tenascin-C deficiency in apo E-/- mouse increases eotaxin levels:implications for atherosclerosis［J］.Atherosclerosis,2013,227(2):267-274.
［17］　ZHANG E,WU Y.Dual effects of miR-155 on macrophages at different stages of atherosclerosis:LDL is the key［J］.Med Hypotheses,2014,83(1):74-78.
［18］　WEI Y,ZHU M,CORBALN-CAMPOS J,et al.Regulation of Csf1r and Bcl6 in macrophages mediates the stage-specific effects of microrna-155 on atherosclerosis［J］.Arterioscler Thromb Vasc Biol,2015,35(4):796-803.
［19］　尚菲,曾德意,杨慧,等.MicroRNA155 通过下调清道夫受体表达抑制巨噬细胞泡沫化形成［J］.中山大学学报（医学科学版）,2012,33(2):156-162.
［20］　TIAN F J,AN L N,WANG G K,et al.Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis［J］.Cardiovasc Res,2014,103(1):100-110.
［21］　WOLFS I M J,DONNERS M,DE WINTHER M P J.Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation［J］.Thromb Haemost,2011,106(5):763.
［22］　NAZARI-JAHANTIGH M,EGEA V,SCHOBER A,et al.MicroRNA-specific regulatory mechanisms in atherosclerosis［J］.J Mol Cell Cardiol,2015,89（Pt A）:35-41.
［23］　NAZARI-JAHANTIGH M,WEI Y,NOELS H,et al.MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages［J］.J Clin Invest,2012,122(11):4190.
［24］　HUSSEIN K,BSCHE G,MUTH M,et al.Expression of myelopoiesis-associated microRNA in bone marrow cells of atypical chronic myeloid leukaemia and chronic myelomonocytic leukaemia［J］.Ann Hematol,2011,90(3):307-313.
［25］　DU F,YU F,WANG Y,et al.MicroRNA-155 deficiency results in decreased macrophage inflammation and attenuated atherogenesis in apolipoprotein e-deficient mice［J］.Arterioscler Thromb Vasc Biol,2014,34(4):759-767.
［26］　CHEN T,YAN H,LI Z,et al.MicroRNA-155 regulates lipid uptake,adhesion/chemokine marker secretion and SCG2 expression in oxLDL-stimulated dendritic cells/macrophages［J］.Int J Cardiol,2011,147(3):446-447.
［27］　HUANG R,HU G,LIN B,et al.MicroRNA-155 silencing enhances inflammatory response and lipid uptake in oxidized low-density lipoprotein-stimulated human THP-1 macrophages［J］.J Investig Med,2010,58(8):961-967.
［28］　ZHU J,CHEN T,YANG L,et al.Regulation of microRNA-155 in atherosclerotic inflammatory responses by targeting MAP3K10［J］.PloS One,2012,7(11):e46551.
［29］　ZHU G,YANG L,GUO R,et al.miR-155 inhibits oxidized low-density lipoprotein-induced apoptosis of RAW264.7 cells［J］.Mol Cell Biochem,2013,382(1/2):253-261.
［30］　ZHANG M,LIU F,JIA H,et al.Inhibition of microRNA let-7i depresses maturation and functional state of dendritic cells in response to lipopolysaccharide stimulation via targeting suppressor of cytokine signaling 1［J］.J Immunol,2011,187(4):1674-1683.
［31］　MOORE K J,TABAS I.Macrophages in the pathogenesis of atherosclerosis［J］.Cell,2011,145(3):341-355.
［32］　CHEN T,YAN H,LI Z,et al.MicroRNA-155 regulates lipid uptake,adhesion/chemokine marker secretion and SCG2 expression in oxLDL-stimulated dendritic cells/macrophages［J］.Int J Cardiol,2011,147(3):446-447.
［33］　陈婷.microRNA-155调控oxLDL刺激树突细胞参与动脉粥样硬化免疫炎症反应的作用及机制［D］.杭州：浙江大学,2013.
［34］　LAO K H,ZENG L,XU Q.Endothelial and smooth muscle cell transformation in atherosclerosis［J］.Curr Opin Lipidol,2015,26(5):449-456.
［35］　MARTIN M M,BUCKENBERGER J A,JIANG J,et al.The human angiotensin Ⅱ type 1 receptor+ 1166 A/C polymorphism attenuates microRNA-155 binding［J］.J Biol Chem,2013,288(6):4227.
［36］　CHEN K C,WANG Y S,HU C Y,et al.OxLDL up-regulates microRNA-29b,leading to epigenetic modifications of MMP-2/MMP-9 genes:a novel mechanism for cardiovascular diseases［J］.FASEB J,2011,25(5):1718-1728.
［37］　CAKMAK H A,COSKUNPINAR E,IKITIMUR B,et al.The prognostic value of circulating microRNAs in heart failure:preliminary results from a genome-wide expression study［J］.J Cardiovasc Med,2015,16(6):431-437.
［38］　DUNAND-SAUTHIER I,SANTIAGO-RABER M L,CAPPONI L,et al.silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function［J］.Blood,2011,117(17):4490-4500.
［39］　FOKS A C,FRODERMANN V,TER BORG M,et al.Differential effects of regulatory T cells on the initiation and regression of atherosclerosis［J］.Atherosclerosis,2011,218(1):53-60.
［40］　DRECHSLER M,MEGENS R T A,VAN ZANDVOORT M,et al.Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis［J］.Circulation,2010,122(18):1837-1845.
［41］　GAO Q,JIANG Y,MA T,et al.A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice［J］.J Immunol,2010,185(10):5820-5827.
［42］　FICHTLSCHERER S,DE ROSA S,FOX H,et al.Circulating microRNAs in patients with coronary artery disease［J］.Circ Res,2010,107(5):677-684.
［43］　YAO R,MA Y,DU Y,et al.The altered expression of inflammation-related microRNAs with microRNA-155 expression correlates with Th17 differentiation in patients with acute coronary syndrome［J］.Mol Immunol,2011,8(6):486-495.
［44］　ZHU G,YANG L,GUO R,et al.microRNA-155 is inversely associated with severity of coronary stenotic lesions calculated by the Gensini score［J］.Coron Artery Dis,2014,25(4):304-310.
［45］　GUPTA S K,BANG C,THUM T.Circulating microRNAs as biomarkers and potential paracrine mediators of cardiovascular disease［J］.Circ Cardiovasc Genet,2010,3(5):484-488.
［46］　ARUNACHALAM G,UPADHYAY R,DING H,et al.MicroRNA signature and cardiovascular dysfunction［J］.J Cardiovasc Pharmacol,2015,65(5):419-429.

相似文献/References:

[1]张　敏,李雪琴,马增凤.血清脂质水平测定在肾脏疾病中的意义[J].新乡医学院学报,2000,17(05):346.
[2]张　敏,李雪琴,马增凤.血清脂质水平测定在肾脏疾病中的意义[J].新乡医学院学报,2000,17(05):346.
[3]周延升,李聪辉,李平法,等.维生素对大鼠脂质及脂质过氧化作用的影响[J].新乡医学院学报,2002,19(02):081.
[4]王淑秀,赵长安,许春雷,等.同型半胱氨酸对内皮细胞单核细胞趋化蛋白一1表达的影响[J].新乡医学院学报,2003,20(02):086.
[5]王淑秀,赵长安,许春雷,等.同型半胱氨酸对内皮细胞单核细胞趋化蛋白O1 表达的影响[J].新乡医学院学报,2003,20(02):086.
[6]王淑秀,赵长安,和瑞芝.同型半胱氨酸诱导内皮细胞表达白细胞介素8[J].新乡医学院学报,2003,20(03):158.
[7]李西兴,周延升,时　岚,等.血脂和同型半胱氨酸对家兔动脉粥样硬化形成的影响[J].新乡医学院学报,2003,20(01):005.
[8]李西兴,周延升,时．岚,等.血脂和同型半胱氨酸对家兔动脉粥样硬化形成的影响[J].新乡医学院学报,2003,20(01):005.
[9]徐自超,张哲莹,郭晓静,等.核转录因子-κB在动脉粥样硬化大鼠动脉平滑肌细胞中的表达[J].新乡医学院学报,2009,26(03):235.
[10]张林静,郭金敏,何玉惠,等.沙利度胺抑制动脉粥样硬化的临床效应[J].新乡医学院学报,2014,31(10):809.[doi:10.7683/xxyxyxb.2014.10.011]

更新日期/Last Update: 2016-10-05