[1]王云生,张清媛.三阴型乳腺癌靶向治疗研究进展[J].新乡医学院学报,2016,33(9):815-818.[doi:10.7683/xxyxyxb.2016.09.022]
 WANG Yunsheng,ZHANG Qingyuan.Research progress of targeted therapy for triple negative breast cancer[J].Journal of Xinxiang Medical University,2016,33(9):815-818.[doi:10.7683/xxyxyxb.2016.09.022]
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三阴型乳腺癌靶向治疗研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年9
页码:
815-818
栏目:
综述
出版日期:
2016-08-23

文章信息/Info

Title:
Research progress of targeted therapy for triple negative breast cancer
作者:
王云生张清媛
(哈尔滨医科大学附属肿瘤医院肿瘤内科,黑龙江 哈尔滨 150081)
Author(s):
WANG YunshengZHANG Qingyuan
关键词:
基底细胞样乳腺癌BRCA突变ADP核糖核酸聚合酶抑制剂PI3K抑制剂三阴型乳腺癌靶向治疗
分类号:
R737.9
DOI:
10.7683/xxyxyxb.2016.09.022
文献标志码:
A
摘要:
乳腺癌是女性最常见的恶性肿瘤之一,具有高度异质性。三阴型乳腺癌(TNBC)为其中的亚型,有其独特的临床特征,复发模式与其他乳腺癌亚型不同,预后较差,并伴有BRCA1基因突变。目前的研究已经阐明,TNBC的分子异质性导致了其独特的生物学特点及对化学治疗敏感性的差异,而分子生物学研究也为TNBC的靶向治疗提供了理论基础。国际上虽无针对性的治疗指南,但TNBC有望通过分子靶向治疗取得更好的预后。本文对目前TNBC的靶向治疗进展加以综述。

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更新日期/Last Update: 2016-09-05