[1]张　雷,杨世展,李承宽.2型糖尿病患者周围神经病变相关危险因素分析[J].新乡医学院学报,2016,33(9):792-794.[doi:10.7683/xxyxyxb.2016.09.015]
　ZHANG Lei,YANG Shi-zhan,LI Cheng-kuan.Risk factors analysis on peripheral neuropathy of type 2 diabetes[J].Journal of Xinxiang Medical University,2016,33(9):792-794.[doi:10.7683/xxyxyxb.2016.09.015]
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2型糖尿病患者周围神经病变相关危险因素分析
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年9
页码:
792-794
栏目:
临床研究
出版日期:
2016-08-23

文章信息/Info

Title:
Risk factors analysis on peripheral neuropathy of type 2 diabetes
作者:
张　雷1; 杨世展1; 李承宽2
（1.光山县人民医院神经内科，河南　光山　465450；2.光山县人民医院急诊科，河南　光山　465450）
Author(s):
ZHANG Lei1; YANG Shi-zhan1; LI Cheng-kuan2
（1.Department of Neurology,the People′s Hospital of Guangshan County,Guangshan 465450,Henan Province,China;2.Department of Emergency,the People′s Hospital of Guangshan County,Guangshan 465450,Henan Province,China）
关键词:
2型糖尿病; 糖尿病神经病变; 危险因素
Keywords:
type 2 diabetes mellitus; diabetic neuropathy; risk factors
分类号:
R587.1
DOI:
10.7683/xxyxyxb.2016.09.015
文献标志码:
A
摘要:
目的　探讨2型糖尿病患者周围神经病变的相关危险因素。方法　回顾性分析光山县人民医院 2013年1月至2015年12月收治的236例2型糖尿病患者的临床资料，根据有无合并周围神经病变，将其分为糖尿病周围神经病变（DPN）组（n=156)和糖尿病非合并周围神经病变(NDPN）组（n=80)。收集2组患者年龄、病程、体质量指数（BMI）、血压、血糖、血脂、血尿酸（UA）、糖化血红蛋白(HbAlc)及尿微量白蛋白与肌酐的比(A/C) 等资料，采用单因素和logistic回归分析对相关危险因素进行分析。结果　单因素分析结果显示：DPN组患者的年龄、病程、收缩压（SBP）均大于NDPN组(P<0.05);2组患者BMI及舒张压（DBP）比较差异均无统计学意义（P>0.05）。DPN组餐后2 h血糖（2hPG）、HbA1c、空腹血糖（FBG）、餐后2 h C肽（2hCP）、尿A/C水平均显著高于NDPN组 (P<0.05);2组患者总胆固醇（TC）、三酰甘油（TG）、空腹C肽、UA及24 h尿蛋白水平比较差异均无统计学意义（P>0.05）。Logistic回归分析结果显示：病程、HbA1c、FBG、2hPG、2hCP是DPN发生的独立危险因素(P<0.05)。结论　2型糖尿病患者的病程、HbA1c、FBG、2hPG及2hCP等是DPN发生的独立危险因素，应给予重视和及早干预，以降低DPN的发生。
Abstract:
Objective　To study the related risk factors on peripheral neuropathy of type 2 diabetes.Methods　The clinical data of two hundred and thirty-six patients with type 2 diabetes from January 2013 to December 2015 in Guangshan County People′s Hospital were analyzed retrospectively.Based on with or without peripheral neuropathy,the patients were divided into diabetic peripheral neuropathy (DPN) group （n=156)and non diabetes peripheral neuropathy（NDPN） group (n=80).The data of patients including age,course of disease,body mass index(BMI),blood pressure,blood sugar,blood lipids,blood uric acid(UA),glycosylated hemoglobin (HbAlc) and the ratio of urine trace albumin to creatinine (A/C) were collected.The related risk factors were analyzed with univariate and logistic regression analysis.Results　The univariate analysis results showed that the age,course of disease,systolic blood pressure(SBP),2h postprandial blood glucose (2hPG),glycosylated hemoglobin (HbA1c),fasting blood glucose (FBG),2h postprandial c-peptide(2hCP) and and urine A/C of patients in DPN group were significantly higher than those in NDPN group (P<0.05);there was no statistic difference of the BMI and diastolic blood pressure (DBP) of the patients between the two groups（P>0.05）.Logistic regression analysis results showed that the course of disease,HbA1c，FBG,2hPG and 2hCP were the independent risk factors for the occurrence of DPN (P<0.05).Conclusion　The course of disease,HbA1c，FBG,2hPG and 2hCP of patients with type 2 diabetes are the independent risk factors for the occurrence of DPN.Patients should be given attention and early intervention to reduce the occurrence of DPN.

参考文献/References:

［1］　包艳,李发祥.坎地沙坦联合贝那普利治疗糖尿病肾病并高血压疗效观察［J］.新乡医学院学报,2015,32(1):65-67.
［2］　YANG C P,LIN C C,LI C I,et al.Cardiovascular risk factors increase the risks of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus the taiwan diabetes study［J］.Medicine (Baltimore),2015,94(42):e1783.
［3］　唐键,王博,张玄娥,等.2型糖尿病患者并发糖尿病周围神经病变危险因素分析［J］.中国全科医学,2015，18(30):3657-3661.
［4］　叶任高.内科学［M］.6版.北京：人民卫生出版社，2004：797.
［5］　朱禧星.现代糖尿病学［M］.上海:上海科学技术出版社,2000:333-340.
［6］　李晶艳，周琦，吕红彬.糖尿病早期视网膜神经元退行性病变最新研究进展［J］.眼科新进展，2015，35(5):493-496.
［7］　沈盛县，严宏.糖尿病性白内障与视网膜病变联合治疗的时机和策略［J］.眼科新进展，2015，35(8):791-794.
［8］　袁媛.2 型糖尿病患者糖尿病视网膜病变的预测性因素研究［J］.眼科新进展，2015，35(8):784-786.
［9］　陈时芳.2型糖尿病周围神经病变危险因素探讨及护理［J］.贵州医药,2015,39(10):950-951.
［10］　ROSILIO C,BEN-SAHRA I,BOST F,et al.Metformin:a metabolic disruptor and anti-diabetic drug to target human leukemia［J］.Cancer Lett,2014,346(2):188-196.
［11］　赖璐华,李玉兰.初诊2型糖尿病患者周围神经病变相关危险因素分析［J］.广西医学,2015，37(9):1243-1245.
［12］　范宾科,谢云.糖尿病周围神经病变的相关因素分析［J］.天津医药,2009,37(7):600-601.
［13］　周素艳.老年2型糖尿病周围神经病变危险因素分析［D］.太原：山西医科大学,2014.
［14］　DEHGHANI C,PRITCHARD N,EDWARDS K,et al.Risk factors associated with corneal nerve alteration in type 1 diabetes in the absence of neuropathy:a longitudinal in vivo corneal confocal microscopy study［J］.Cornea,2016,35(6):847-852.
［15］　TIMAR B,TIMAR R,GAITA L,et al.The impact of diabetic neuropathy on balance and on the risk of falls in patients with type 2 diabetes mellitus:a cross-sectional study［J］.PLoS One,2016,11(4):e0154654.
［16］　赫广玉,孙成林,刘玉佳,等.糖尿病周围神经病变神经损害特点及相关因素分析［J］.中国糖尿病杂志,2014，22(2):118-121.
［17］　吴群励，梁晓春.糖尿病周围神经病变发病机制及中药复方筋脉通胶囊对其干预作用的研究进展［J］.中国中西医结合杂志，2014，34(11):1401-1404.

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更新日期/Last Update: 2016-09-05