[1]王晋萍,李占辉.丹参注射液和硫酸镁联合治疗对妊娠期高血压疾病患者分娩结局及血清脂联素表达的影响[J].新乡医学院学报,2016,33(9):764-766.[doi:10.7683/xxyxyxb.2016.09.006]
　WANG Jin-ping,LI Zhan-hui.Effect of Danshen injection combined with magnesium sulfate on the outcome of childbirth and serum adiponectin in patients with hypertensive disorders of pregnancy[J].Journal of Xinxiang Medical University,2016,33(9):764-766.[doi:10.7683/xxyxyxb.2016.09.006]
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丹参注射液和硫酸镁联合治疗对妊娠期高血压疾病患者分娩结局及血清脂联素表达的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年9
页码:
764-766
栏目:
临床研究
出版日期:
2016-08-23

文章信息/Info

Title:
Effect of Danshen injection combined with magnesium sulfate on the outcome of childbirth and serum adiponectin in patients with hypertensive disorders of pregnancy
作者:
王晋萍; 李占辉
（北京市丰台中西医结合医院妇产科，北京　100072）
Author(s):
WANG Jin-ping; LI Zhan-hui
（Department of Gynaecology and Obstetrics，Beijing Fengtai Hospital of Integrated Traditional and Western Medicine，Beijng 100072，China）
关键词:
丹参注射液; 硫酸镁; 脂联素; 妊娠期高血压疾病
Keywords:
danshen injection; magnesium sulfate; adiponectin; hypertensive disorders of pregnancy
分类号:
R714.24+6
DOI:
10.7683/xxyxyxb.2016.09.006
文献标志码:
A
摘要:
目的　探讨丹参注射液和硫酸镁联合治疗妊娠期高血压疾病的治疗效果及对脂联素的调控和分娩结局的影响。方法　选取2014年6月至2016年2月北京市丰台中西医结合医院的收治104例妊娠期高血压疾病患者为研究对象，按随机数字表法将患者分为对照组（50例）和观察组（54例）。对照组患者在常规治疗基础上加用硫酸镁治疗，观察组患者在对照组治疗基础上给予丹参注射液治疗，持续用药7 d后比较2组患者血压变化情况和剖宫产、早产、产后出血、新生儿宫内窘迫发生情况，同时用放射免疫法检测血清脂联素水平。结果　治疗前2组患者收缩压、舒张压比较差异无统计学意义（P>0.05）；治疗后观察组患者收缩压、舒张压均显著低于对照组（P<0.05）。治疗后观察组患者血清脂联素水平为（10.68±4.56）mg·L-1，较治疗前的（7.85±3.12）mg·L-1、对照组的（8.76±3.91） mg·L-1均明显升高（P<0.05）。观察组患者剖宫产、早产、产后出血、新生儿宫内窘迫发生率均显著低于对照组（P<0.05）。结论　丹参注射液联合硫酸镁对妊娠期高血压疾病患者有良好的临床疗效，可能通过调节血清脂联素水平发挥作用。
Abstract:
Objective　To investigate the treatment effectiveness of Danshen injection combined with magnesium sulfate in treatment of hypertensive disorders of pregnancy and observe the effect of it on the outcome of childbirth and serum adiponectin.Methods　One hundred and four patients with hypertensive disorders of pregnancy were selected as the research object from June 2014 to February 2016 in Fengtai Beijing Integrated Traditional Chinese and Western Medicine Hospital.The patients were randomly divided into control group（n=50） and observation group（n=54）.All patients were given conventional therapy，based on this，the patients in control group were given magnesium sulfate；the patients in observation group were given Danshen injection and magnesium sulfate.All patients were treated for 7 days，then the blood pressure changes and incidence of cesarean section，premature delivery，postpartum hemorrhage，fetal distress neonatal cases were compared between the two groups.Besides，the adiponectin levels were detected by radio-immunity method.Results　Before treatment，there was no statistic difference of the systolic blood pressure and diastolic blood pressure of the patients between the two groups（P>0.05）.After treatment，the systolic blood pressure and diastolic blood pressure of the patients in observation group was significantly lower than that in control group（P<0.05）.After treatment，the adiponectin level in observation group was（10.68±4.56）mg·L-1，which was significantly higher than before treatment［（7.85±3.12）mg·L-1］ and control group［（8.76±3.91） mg·L-1］（P<0.05）.The incidence of cesarean section，premature delivery，postpartum hemorrhage，intrauterine distress in observation group was significantly lower than that in the control group（P<0.05）.Conclusion　Danshen injection combined with magnesium sulfate has good effect in treatment of the patients with hypertensire disorders of pregnancy.It may play a role by regulating serum adiponectin levels.

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更新日期/Last Update: 2016-09-05