[1]于 乐.膝骨关节炎患者血清脂肪因子水平与颈动脉硬化的相关性[J].新乡医学院学报,2016,33(8):701-703.[doi:10.7683/xxyxyxb.2016.08.014]
 YU Le.Correlation between serum adipokines levels and carotid atherosclerosis in patients with knee osteoarthritis[J].Journal of Xinxiang Medical University,2016,33(8):701-703.[doi:10.7683/xxyxyxb.2016.08.014]
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膝骨关节炎患者血清脂肪因子水平与颈动脉硬化的相关性
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年8
页码:
701-703
栏目:
临床研究
出版日期:
2016-07-27

文章信息/Info

Title:
Correlation between serum adipokines levels and carotid atherosclerosis in patients with knee osteoarthritis
作者:
于 乐
(铜川矿务局中心医院骨外科,陕西 铜川 727000)
Author(s):
YU Le
(Department of Orthopaedics,the Central Hospital of Tongchuan Mining Bureau,Tongchuan 727000,Shaanxi Province,China)
关键词:
膝骨关节炎瘦素抵抗素内脏脂肪素脂肪因子动脉硬化颈动脉
Keywords:
knee osteoarthritisleptinresistinvisfatinadipokinesatherosclerosiscarotid
分类号:
R684.3
DOI:
10.7683/xxyxyxb.2016.08.014
文献标志码:
A
摘要:
目的 探讨膝骨关节炎患者血清脂肪因子水平与颈动脉硬化的相关性。方法 选择2013年1月至2015年1月铜川矿务局中心医院收治的膝骨关节炎患者62例(膝骨关节炎组),另选择同期体检健康者30例为对照组,对2组受试者血清内脏脂肪素、抵抗素、瘦素及颈动脉内膜中层厚度(IMT)和内径进行比较,并分析血清内脏脂肪素、抵抗素、瘦素水平与颈动脉硬化的相关性。结果 膝骨关节炎组患者血清内脏脂肪素、抵抗素、瘦素水平显著高于对照组(P<0.05);Ⅲ级膝骨关节炎患者血清内脏脂肪素、抵抗素、瘦素水平显著高于Ⅱ级患者(P<0.05),Ⅳ级膝骨关节炎患者血清内脏脂肪素、瘦素水平显著高于Ⅱ、Ⅲ级患者(P<0.05);Ⅳ级膝骨关节炎患者血清抵抗素水平显著高于Ⅱ级患者(P<0.05),但Ⅲ、Ⅳ级膝骨关节炎患者血清抵抗素水平比较差异无统计学意义(P>0.05)。膝骨关节炎组患者颈动脉IMT显著大于对照组(P<0.05);Ⅲ级膝骨关节炎患者颈动脉IMT显著大于Ⅱ级患者(P<0.05),Ⅳ级膝骨关节炎患者颈动脉IMT显著大于Ⅱ、Ⅲ级患者(P<0.05)。膝骨关节炎组与对照组颈动脉内径比较差异无统计学意义(P>0.05),Ⅱ、Ⅲ、Ⅳ级膝骨关节炎患者颈动脉内径比较差异均无统计学意义(P>0.05)。Sperman相关性分析显示,膝骨关节炎患者血清内脏脂肪素和瘦素水平与颈动脉IMT呈显著正相关(r=0.307、0.356,P<0.05),血清抵抗素水平与颈动脉IMT无显著相关性(r=0.132,P>0.05);膝骨关节炎患者血清内脏脂肪素、瘦素、抵抗素水平与颈动脉内径均无显著相关性(r=0.076、0.015、0.067,P>0.05)。结论 脂肪因子水平升高是膝骨关节炎损害进展的危险因素,且该过程与颈动脉硬化存在密切关系。
Abstract:
Objective To study the correlation between serum adipokines levels and carotid atherosclerosis in patients with knee osteoarthritis.Methods Sixty-two patients with knee osteoarthritis(knee osteoarthritis group) in the Central Hospital of Tongchuan Mining Bureau were selected from January 2013 to January 2015.Thirty healthy subjects were selected as control group.The levels of serum visfatin,resistin,leptin and the intima-media thickness(IMT),internal diameter of carotid were detected.The relationship between serum visfatin,resistin,leptin and carotid atherosclerosis was analyzed.Results The levels of serum visfatin,resistin and leptin in knee osteoarthritis group were significantly higher than those in control group(P<0.05).The levels of serum visfatin,resistin and leptin in patients with knee osteoarthritis of grade Ⅲ were significantly higher than those in patients with knee osteoarthritis of grade Ⅱ(P<0.05).The levels of serum visfatin and leptin in patients with knee osteoarthritis of grade Ⅳ were significantly higher than those in patients with knee osteoarthritis of grade Ⅱ and Ⅲ(P<0.05).The level of serum resistin in patients with knee osteoarthritis of grade Ⅳ was significantly higher than that in patients with knee osteoarthritis of grade Ⅱ(P<0.05).But there was no significant difference in the serum resistin level between the patients with knee osteoarthritis of grade Ⅲ and Ⅳ(P>0.05).The carotid IMT in knee osteoarthritis group was significantly higher than that in control group(P<0.05).The carotid IMT in patients with knee osteoarthritis of grade Ⅲ was significantly higher than that in patients with knee osteoarthritis of grade Ⅱ(P<0.05).The carotid IMT in patients with knee osteoarthritis of grade Ⅳ was significantly higher than that in patients with knee osteoarthritis of grade Ⅱ and Ⅲ(P<0.05).There was no significant difference in the internal diameter of carotid between knee osteoarthritis group and control group(P>0.05).There was no significant difference in the internal diameter of carotid between the patients with knee osteoarthritis of grade Ⅱ,Ⅲ and Ⅳ(P>0.05).Sperman correlation analysis showed that the levels of serum visfatin and leptin were significantly positively correlated to the carotid IMT(r=0.307,0.356;P<0.05),but there was no significant correlation between the serum resistin level and carotid IMT in patients with knee osteoarthritis(r=0.132,P>0.05).There was no significant correlation between the levels of serum visfatin,resistin,leptin and internal diameter of carotid in patients with knee osteoarthritis(r=0.076,0.015,0.067;P>0.05).Conclusion Adipokines level up-regulation is the risk factor for the progression of knee osteoarthritis,and the process is closely related to carotid atherosclerosis.

参考文献/References:

[1] YOKOGAWA N,TORIBATAKE Y,MURAKAMI H,et al.Differences in gait characteristics of patients with lumbar spinal canal stenosis(L4 radiculopathy) and those with osteoarthritis of the hip[J].PLoS One,2015,10(4):e124745.
[2] JONSSON H,HELGADOTTIR G P,ASPELUND T,et al.The presence of total knee or hip replacements due to osteoarthritis enhances the positive association between hand osteoarthritis and atherosclerosis in women:the AGES-Reykjavik study[J].Ann Rheum Dis,2011,70(6):1087-1090.
[3] 中华医学会骨科学分会.骨关节炎诊治指南:2007年版[J].中华骨科杂志,2007,27(10):793-796.
[4] 赵全明,王伟卓,郭雄.PAPSS2在大骨节病和骨关节炎疾病中作用机制的研究进展[J].国外医学:医学地理分册,2012,33(2):79-82.
[5] GIERMAN L M,KUHNAST S,KOUDIJS A,et al.Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice:a translational model for atherosclerosis[J].Ann Rheum Dis,2014,73(5):921-927.
[6] 姚筱,马玮娟,郭雄.氧化应激与关节软骨损伤关系的研究进展[J].国外医学:医学地理分册,2013,34(3):151-153,183.
[7] HOEVEN T A,KAVOUSI M,IKRAM M A,et al.Markers of atherosclerosis in relation to presence and progression of knee osteoarthritis:a population-based cohort study[J].Rheumatology(Oxford),2015,54(9):1692-1698.
[8] GKRETSI V,SIMOPOULOU T,TSEZOU A.Lipid metabolism and osteoarthritis:lessons from atherosclerosis[J].Prog Lipid Res,2011,50(2):133-140.
[9] CEMEROGLU O,AYDIN H I,YASAR Z S,et al.Hand and heart,hand in hand:is radiological hand osteoarthritis associated with atherosclerosis[J].Int J Rheum Dis,2014,17(3):299-303.
[10] KOUTROUMPAS A,GIANNOUKAS A,ZINTZARAS E,et al.Erosive hand osteoarthritis is associated with subclinical atherosclerosis and endothelial dysfunction[J].Int J Biomed Sci,2013,9(4):217-223.
[11] 唐建,罗清礼.瘦素基因在甲状腺相关眼病眶脂肪及体外分化眶脂肪细胞中的表达[J].眼科新进展,2014,34(9):801-804.
[12] REGISTER T C,CARLSON C S,ADAMS M R.Serum YKL-40 is associated with osteoarthritis and atherosclerosis in nonhuman primates[J].Clin Chem,2014,47(12):2159-2161.
[13] HOEVEN T A,KAVOUSI M,CLOCKAERTS S,et al.Association of atherosclerosis with presence and progression of osteoarthritis:the Rotterdam study[J].Ann Rheum Dis,2013,72(5):646-651.
[14] JONSSON H,HELGADOTTIR G P,ASPELUND T,et al.Hand osteoarthritis in older women is associated with carotid and coronary atherosclerosis:the AGES Reykjavik study[J].Ann Rheum Dis,2013,68(11):1696-1700.

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更新日期/Last Update: 2016-08-05