[1]何国军,符益纲,左其龙,等.D-二聚体在颅内静脉窦血栓形成中的临床意义[J].新乡医学院学报,2016,33(7):620-622.[doi:10.7683/xxyxyxb.2016.07.019]
　HE Guo-jun,FU Yi-gang,ZUO Qi-long,et al.Clinical significance of D-dimmer in cerebral venous sinus thrombosis[J].Journal of Xinxiang Medical University,2016,33(7):620-622.[doi:10.7683/xxyxyxb.2016.07.019]
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D-二聚体在颅内静脉窦血栓形成中的临床意义
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年7
页码:
620-622
栏目:
临床研究
出版日期:
2016-07-05

文章信息/Info

Title:
Clinical significance of D-dimmer in cerebral venous sinus thrombosis
作者:
何国军1; 符益纲2; 左其龙1; 龚筱倩1; 孙士富1; 高　阳1; 黄小鹏1
（1.盐城市第一人民医院神经内科，江苏　盐城　224001；2.盐城市第一人民医院核磁共振室，江苏　盐城　224001）
Author(s):
HE Guo-jun1; FU Yi-gang2; ZUO Qi-long1; GONG Xiao-qian1; SUN Shi-fu1; GAO Yang1; HUANG Xiao-peng1
(1.Department of Neurology，the First People′s Hospital of Yancheng City，Yancheng 224001，Jiangsu Province，China；2.Department of Magnetic Resonance Imaging，the First People′s Hospital of Yancheng City，Yancheng 224001，Jiangsu Province，China)
关键词:
D-二聚体; 颅内静脉窦血栓形成; 抗凝治疗
Keywords:
D-dimmer; cerebral venous sinus thrombosis; anticoagulant therapy
分类号:
R651.1
DOI:
10.7683/xxyxyxb.2016.07.019
文献标志码:
A
摘要:
目的　探讨D-二聚体（D-D）在颅内静脉窦血栓形成(CVST)中的临床意义。方法　选择2008年1月至2014年7月在盐城市第一人民医院经磁共振成像和磁共振静脉成像检查确诊的CVST患者28例，所有患者给予抗凝治疗14 d，观察治疗前后血清D-D水平变化。结果　28例患者抗凝治疗14 d后，静脉窦完全再通6例（完全再通组），部分再通18例（部分再通组），未再通4例（未再通组），再通率为85.71%（24/28）。完全再通组、部分再通组患者抗凝治疗后血清D-D水平均显著降低（P<0.01），而未再通组患者治疗前后血清D-D水平比较差异无统计学意义（P>0.05）。抗凝治疗第8、14天，完全再通组、部分再通组患者血清D-D水平显著低于未再通组（P<0.01）。结论　CVST患者抗凝治疗后血清D-D水平显著降低提示静脉窦完全或部分再通，预后良好。D-D可作为CVST患者疗效评价的一项指标。
Abstract:
Objective　To explore the clinical significance of D-dimmer(D-D) in cerebral venous sinus thrombosis(CVST).Methods　A total of 28 patients with CVST diagnosed by magnetic resonance imaging and magnetic resonance angiography were selected in the First People′s Hospital of Yancheng City from January 2008 to July 2014.All the patients were given anticoagulant therapy for 14 days，and the change of serum D-D level was observed before and after treatment.Results　A total of 28 cases were given anticoagulant therapy for 14 days.There were six cases of complete revascularization(complete revascularization group)，eighteen cases of partial revascularization(partial revascularization group) and four cases of non-revascularization(non-revascularization group) after treatment，the rate of revascularization was 85.71%(24/28).The serum D-D level in complete revascularization group and partial revascularization group decreased significantly after anticoagulant therapy(P<0.01)，but there was no significant difference in serum D-D level before and after treatment in non-revascularization group(P>0.05).After anticoagulation therapy for eight and fourteen days，the serum D-D level in complete revascularization group and partial revascularization group was significantly lower than that in non-revascularization group(P<0.01).Conclusion　The serum D-D level of patients with CVST decrease significantly after anticoagulation indicate complete revascularization and partial revascularization.D-D can be used as an biomarker for the evaluation of curative effect in CVST patients.

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更新日期/Last Update: 2016-07-05