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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:

33

期数:

2016年7

页码:

613-615

栏目:

临床研究

出版日期:

2016-07-05

文章信息/Info

Title:

Thrombogenesis character of metabolic syndrome patients with different level of hypertension

作者:

朱宝琛¹; 师　帅²; 王　欢²; 张菀桐²

(1.中国中医科学院西苑医院基础医学研究所，北京　100091；2.中国中医科学院广安门医院，北京　100053)

Author(s):

ZHU Bao-chen¹; SHI Shuai²; WANG Huan²; ZHANG Wan-tong²

（1.Institute of Basic Medical Sciences，Xiyuan Hospital，China Academy of Chinese Medical Science，Beijing 100091，China；2.Guang′anmen Hospital，China Academy of Chinese Medical Science，Beijing 100053，China）

关键词:

代谢综合征; 高血压分级; 血栓风险; 血栓弹力图

Keywords:

metabolic syndrome; hypertension degree; throbogenesis risk; thrombelastogram

分类号:

R589

DOI:

10.7683/xxyxyxb.2016.07.017

文献标志码:

A

摘要:

目的　运用不同的凝血功能检测方法评价代谢综合征合并不同等级高血压患者的血栓形成风险，从而指导临床用药。方法　将169例代谢综合征患者分为高血压1级组（MS1组）48例、高血压2级组（MS2组）39例、高血压3级组（MS3组）42例和非高血压组（MS0组）40 例，对4组患者分别进行凝血功能检测、血小板参数分析以及血栓弹力图参数检验，并进行比较，判断代谢综合征合并不同等级高血压患者的血栓形成风险。结果　MS0组患者组间血凝块形成时间（K）、最大振幅（MA）确定后30 min内血凝块幅度减少速率（LY30）高于MS1组、MS2组和MS3组（P<0.05）；MS0组患者描记图最大曲线弧度作切线与水平线的夹角（Angle）低于MS1组、MS2组和MS3组（P<0.05），MS1组患者Angle值低于MS3组（P<0.05）；MS0组、MS1组、MS2组、MS3组患者MA值依次升高，两两比较差异均有统计学意义（P<0.05）；MS0组患者预测在MA确定后30 min内血凝块将要溶解百分数高于MS1组、MS2组和MS3组（P<0.05）；MS0组、MS1组、MS2组、MS3组患者凝血反应时间两两比较差异无统计学意义（P>0.05）。MS0组、MS1组、MS2组患者血浆纤维蛋白原均低于MS3组（P<0.05）；MS0组患者血小板（PLT）计数低于MS2组和MS3组（P<0.05），MS1组患者PLT计数低于MS3组（P<0.05）；各组患者凝血酶原时间、活化部分凝血活酶时间、国际标准化比值、血小板体积分布宽度、平均血小板体积及大血小板比率比较差异无统计学意义（P>0.05）。结论　代谢综合征合并高血压患者具有较高的血栓形成风险，其风险值随血压等级的升高而升高，对于代谢综合征患者，应积极控制血压，预防血栓事件的发生。

Abstract:

Objective　To discuss thrombogenesis risk in metabolic syndrome (MS) patients with different level of hypertension by detecting coagulation function with different method in order to give advisement for clinical treatment.Methods　One hundred and sixty-nine patients were chosen and divided into MS with first level hypertension group(MS1 group，n=48)，MS with second lever hypertension (MS2 group，n=39)，MS with third hypertension (MS3 group，n=42) and MS with non-hypertension(MS0 group，n=40).The coagulation function，platelet parameter thrombelastogram were detected in the four groups and the results were compared to evaluate the thrombogenesis risk of MS patients with different level of hypertension.Results　The levels of K and LY30 in MS0 group were higher than those in MS1 group，MS2 group and MS3 group（P<0.05）.The level of Angle in MS0 group was lower than that in MS1 group，MS2 group and MS3 group（P<0.05），and the level of Angle in MS1 group was lower than that in MS3 group（P<0.05）.The level of maximum amplitude(MA) in MS0 group，MS1 group，MS2 group，MS3 group increased in order，and there was significant difference of it comparison between any two groups（P<0.05）.The level of estimate percent lysis in MS0 group was higher than that in MS1 group，MS2 group and MS3 group（P<0.05）.There was no significant difference of R comparison between any two groups（P>0.05）.The level of fibrinogen in MS0 group，MS1 group and MS2 group was lower than that in MS3 group(P<0.05).The level of platelet in MS0 group was lower than that in MS2 group and MS3 group(P<0.05)；and it was lower in MS1 group compared with MS3 group(P<0.05).There was no significant difference in prothrombin time，activated partial thromboplastin time，international normalized ratio，platelet distribution width，mean platelet volume and platelet-large cell rate among the four groups(P>0.05).Conclusion　MS patients with of hypertension have a high risk of thrombogenesis and it is necessary to give effective treatment to control the blood pressure and reduce the incidence of throbogenesis.

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更新日期/Last Update: 2016-07-05