[1]吕婷婷,王新友,王长虹.低频重复经颅磁刺激联合帕罗西汀治疗伴焦虑症状抑郁障碍患者疗效观察[J].新乡医学院学报,2016,33(7):589-592.[doi:10.7683/xxyxyxb.2016.07.010]
　LYU Ting-ting,WANG Xin-you,WANG Chang-hong.Efficacy of paroxetine combined with the low frequency repetitive transcranial magnetic stimulation in the treatment of depressive disorder patients with anxiety symptoms[J].Journal of Xinxiang Medical University,2016,33(7):589-592.[doi:10.7683/xxyxyxb.2016.07.010]
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低频重复经颅磁刺激联合帕罗西汀治疗伴焦虑症状抑郁障碍患者疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年7
页码:
589-592
栏目:
临床研究
出版日期:
2016-07-05

文章信息/Info

Title:
Efficacy of paroxetine combined with the low frequency repetitive transcranial magnetic stimulation in the treatment of depressive disorder patients with anxiety symptoms
作者:
吕婷婷1; 王新友2; 王长虹1
（1.新乡医学院第二附属医院，河南　新乡　453002；2.新乡医学院第二附属医院精神科，河南　新乡　453002）
Author(s):
LYU Ting-ting1; WANG Xin-you2; WANG Chang-hong1
(1.The Second Affiliated Hospital of Xinxiang Medical University，Xinxiang 453002，Henan Province，China；2.Department of Psychiatry，the Second Affiliated Hospital of Xinxiang Medical University，Xinxiang 453002，Henan Province，China)
关键词:
重复经颅磁刺激; 帕罗西汀; 焦虑; 抑郁
Keywords:
repetitive transcranial magnetic stimulation; paroxetine; anxiety; depressive disorder
分类号:
R749.059
DOI:
10.7683/xxyxyxb.2016.07.010
文献标志码:
A
摘要:
目的　探讨低频重复经颅磁刺激（rTMS）联合帕罗西汀治疗伴有焦虑症状抑郁障碍患者的疗效及安全性。方法　将伴有焦虑症状的抑郁障碍患者90例随机分为帕罗西汀+rTMS治疗组（A组）、帕罗西汀+伪rTMS治疗组（B组）和帕罗西汀治疗组（C组）。3组患者均接受6周帕罗西汀（10 mg·d-1）治疗，在此基础上，A组患者接受右侧前额叶背外侧rTMS刺激（1 Hz），刺激时间15 s，间歇5 s，每周5次，连续6周。B组患者应用的刺激线圈、刺激部位、次数、频率与A组相同，但只有振动声音，不产生磁场效应。于治疗前和治疗第2、4、6周末采用汉密尔顿焦虑量表（HAMA）和汉密尔顿抑郁量表（HAMD）评价疗效。结果　治疗6周末3组患者治疗总有效率比较差异均无统计学意义（P>0.05）。治疗前3组患者HAMD、HAMA评分比较差异均无统计学意义（P>0.05）。治疗2周末，A、B组患者HAMD和 HAMA评分低于C组（P<0.05）；A组与B组患者HAMD、HAMA评分比较差异无统计学意义（P>0.05）。治疗4周末，A组患者HAMD评分低于B、C组（P<0.05），B组与C组患者HAMD比较差异无统计学意义（P>0.05）；A组患者HAMA评分低于C组（P<0.05），B组患者与A、C组比较差异无统计学意义（P>0.05）。治疗6周末，A组患者HAMD、HAMA评分低于B、C组（P<0.05），B组与C组患者HAMD、HAMA比较差异无统计学意义（P>0.05）。治疗期间3组患者均未发生严重不良反应。A、B、C组患者不良反应发生率分别为35.7%（10/28）、41.4%（12/29）、50.0%（14/28），3组不良反应发生率比较差异无统计学意义（P>0.05）。结论　低频rTMS联合帕罗西汀治疗伴焦虑症状抑郁障碍患者有效率高，且不良反应少。
Abstract:
Objective　To observe the efficacy and safety of paroxetine combined with low frequency repetitive transcranial magnetic stimulation （rTMS） for treatment of the depressive disorder patients with anxiety symptoms.Methods　Ninety depressive disorder patients with anxiety symptoms were randomly divided into the paroxetine combined with rTMS group (group A)，paroxetine combined with unreal rTMS group(group B) and paroxetine group (group C).All patients were given paroxetine(10 mg·d-1) for six weeks；based on this，the patients in group A were given rTMS (1 Hz，stimulating 15 s and interval 5 s)on the right dorsolateral prefrontal for 20 min，5 times per week for six weeks；and the patients in group B were given unreal stimulation which was the same with the group A in the coil，site of stimulation，number，frequency；however，without any magnetic field.Hamilton Depression Rating Scale（HAMD) and Hamilton Anxiety Rating Scale (HAMA) were used to assess the efficacy before treatment and 2，4，6 weeks after treatment.Results　There was no statistic difference of the effectiveness rate of patients at the 6 weeks after treatment among the three groups（P>0.05）.There was no statistic differences of the HAMD and HAMA scores before treatment among the three groups（P>0.05）.At the end of the 2nd weeks，the HAHA and HAMD scores of patients in group A and group B were significantly lower than those in group C（P<0.05）；but there was no statistic difference of the HAHA and HAMD scores between group A and group B（P>0.05）.At the end of the 4th weeks，the HAMD scores of patients in group A were significantly lower than those in group B and group C（P<0.05）；there was no statistic difference of the HAMD scores between group B and group C (P>0.05）；the HAMA scores of patients in group A were significantly lower than those in group C（P<0.05）；there was no statistic difference of the HAMA scores between the group B and group A，group C (P>0.05）.At the end of the 6th weeks，the HAHA and HAMD scores of patients in group A was significantly lower than those in group B and group C（P<0.05）；there was no statistic difference of the HAHA and HAMD scores between group B and group C (P>0.05）.All the patients had no severe adverse reactions during treatment.The incidence of adverse reaction of patients in the group A，B，C was 35.7%(10/28)，41.4%(12/29) and 50.0%(14/28) respectively；there was no statistic difference of incidence of adverse reactions among the three groups(P>0.05）.Conclusion　Low frequency rTMS combined with paroxetine for treatment of the depressive disorder patients with anxiety symptoms have higher effectiveness rate and lower side effects.

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更新日期/Last Update: 2016-07-05