[1]杨慧孟,娄 阁.一氧化氮供体治疗骨质疏松症研究进展[J].新乡医学院学报,2016,33(6):548-551.[doi:10.7683/xxyxyxb.2016.06.029]
 YANG Huimeng,LOU Ge.Research progress of nitric oxide donor in the treatment of osteoporosis[J].Journal of Xinxiang Medical University,2016,33(6):548-551.[doi:10.7683/xxyxyxb.2016.06.029]
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一氧化氮供体治疗骨质疏松症研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年6
页码:
548-551
栏目:
综述
出版日期:
2016-06-05

文章信息/Info

Title:
Research progress of nitric oxide donor in the treatment of osteoporosis
作者:
杨慧孟娄 阁
(哈尔滨医科大学附属第三医院妇科,黑龙江 哈尔滨 150081)
Author(s):
YANG HuimengLOU Ge
关键词:
骨质疏松症一氧化氮供体药物治疗
分类号:
R681
DOI:
10.7683/xxyxyxb.2016.06.029
文献标志码:
A
摘要:
骨质疏松症是一种骨重塑增加的疾病,骨吸收与骨形成不平衡,且骨吸收大于骨形成,导致骨密度降低及骨微结构破坏。目前,骨质疏松症的治疗存在明显缺陷,需要研究新的抗骨质疏松药物。研究发现,雌激素对骨的一些效应是由一氧化氮(NO)介导的,NO供体是治疗骨质疏松症的一种新策略。本文对NO供体治疗骨质疏松症的研究进展进行综述。

参考文献/References:

[1] MPALARIS V,ANAGNOSTIS P,GOULIS D G,et al.Complex association between body weight and fracture risk in postmenopausal women[J].Obesity Rev,2015,16(3):225-233.
[2] METGE C J,LESLIE W D,MANNESS L J,et al.Postfracture care for older women:gaps between optimal care and actual care[J].Can Fam Physician,2008,54(9):1270-1276.
[3] CARRADORI S,MOLLICA A,DE MONTE C,et al.Nitric oxide donors and selective carbonic anhydrase inhibitors:a dual pharmacological approach for the treatment of glaucoma,cancer and osteoporosis[J].Molecules,2015,20(4):5667-5679.
[4] JOHNELL O,KANIS J A.An estimate of the worldwide prevalence and disability associated with osteoporotic fractures[J].Osteoporos Int,2006,17(12):1726-1733.
[5] GULLBER B,JOHNELL O,KANIS J A.World-wide projections for hip fracture[J].Osteoporos Int,1997,7(5):407-413.
[6] IAMAL S A,HAMILTON C J.Nitric oxide donors for the treatment of osteoporosis[J].Curr Osteoporos Rep,2012,10(1):86-92.
[7] SATTERWITHE J,HEATHMAN M,MILLER P D,et al.Pharmacokinetics of teriparatide[rhPTH(1-34)] and calcium pharmacodynamics in postmenopausalwomen with osteoporosis[J].Calcif Tissue Int,2010,87(6):485-492.
[8] VAHLE J L,LONG G G,SANDUSKY G,et al.Bone neoplasms in F344 rats given teriparatide[rhPTH(1-34)] are dependent on duration of treatment and dose[J].Toxicol Pathol,2004,32(4):426-438.
[9] MILLER P D.Safety of parathyroid hormone for the treatment of osteoporosis[J].Curr Osteoporos Rep,2008,6(1):12-16.
[10] MAJUMDAR S R,MCALISTER F A,JOHNSON J A,et al.Critical impact of patient knowledge and bone density testing on starting osteoporosis treatment after fragility fracture:secondary analyses from two controlled trials[J].Osteoporos Int,2014,25(9):2173-2179.
[11] EVANS D M,RALSTON S H.Nitric oxide and bone[J].J Bone Miner Res,1996,11(3):300-305.
[12] CHAE H J,PARK R K,CHUNG H T,et al.Nitric oxide is a regulator of bone remodelling[J].J Pharm Pharmacol,1997,49(9):897-902.
[13] PALMER R M,FERRIGE A G,MONCADA S.Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor[J].Nature,1987,327(6122):524-526.
[14] GHASEMI M,NEMATBAKHSH M,DANESHMAND F A,et al.Role of nitric oxide in kidney and liver(as distance organ) function in bilateral renal ischemia-reperfusion:effect of L-arginine and NG-nitro-L-arginine methyl ester[J].Adv Biomed Res,2015,4:233.
[15] HSU Y C,LEE P H,LEI C C,et al.Nitric oxide donors rescue diabetic nephropathy through oxidative-stress-and nitrosative-stress-mediated Wnt signaling pathways[J].J Diabetes Investig,2015,6(1):24-34.
[16] ROGERS N E,IGNARRO L J.Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from arginine[J].Biochem Biophys Res Commun,1992,189(1):242-249.
[17] LIPTON S A,CHOI Y B,PAN Z H,et al.A redox based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso compounds[J].Nature,1993,364(6438):626-632.
[18] WINDHAUSEN T,SQUIFFLET S,RENN J,et al.BMP Signaling regulates bone morphogenesis in zebrafish through promoting osteoblast function as assessed by their nitric oxide production[J].Molecules,2015,20(5):7586-7601.
[19] KOHGAMI S,OGATA T,MORINO T,et al.Pharmacological shift of the ambiguous nitric oxide action from neurotoxicity to cyclic GMP-mediated protection[J].Neurol Res,2010,32(9):938-944.
[20] MANCINI L,MORADI-BIDHENDI N,BECHERINI L,et al.The biphasic effects of nitric oxide in primary rat osteoblasts are cGMP dependent[J].Biochem Biophys Res Commun,2000,274(2):477-481.
[21] RALSTON S H,HO L P,HELFRICH M H,et al.Nitric oxide:a cytokine-induced regulator of bone resorption[J].J Bone Miner Res,1995,10(7):1040-1049.
[22] BRANDI M L,HUKKANEN M,UMEDA T,et al.Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms[J].Proc Natl Acad Sci USA,1995,92(7):2954-2958.
[23] ARMOUR K E,VAT′T HOF R J,GRABOWSKI P S,et al.Evidence for a pathogenic role of nitric oxide in inflammation induced osteoporosis[J].J Bone Miner Res,1999,14(12):2137-2142.
[24] VAN′T HOF R J,ARMOUR K J,SMITH L M,et al.Requirement of the inducible nitric oxide synthase pathway for IL-1-induced osteoclastic bone resorption[J].Proc Natl Acad Sci USA,2000,97(14):7993-7998.
[25] VAN′T HOF R J,RALSTON S H.Cytokine-induced nitric oxide inhibits bone resorption by inducing apoptosis of osteoclast progenitors and suppressing osteoclast activity[J].J Bone Miner Res,1997,12(11):1797-1804.
[26] PERCIVAL M D,OUELLET M,CAMPAGNOLO C,et al.Inhibition of cathepsin K by nitric oxide donors:evidence for the formation of mixed disulfides and a sulfenic acid[J].Biochemistry,1999,38(41):13574-13583.
[27] RIANCHO J A,SALAS E,ZARRABEITIA M T,et al.Expression and functional role of nitric oxide synthase in osteoblast-like cells[J].J Bone Miner Res,1995,10(3):439-446.
[28] MANCINI L,MORADI-BIDHENDI N,BECHERINI L,et al.The biphasic effects of nitric oxide in primary rat osteoblasts are cGMP dependent[J].Biochem Biophys Res Commun,2000,274(2):477-481.
[29] JOSHUA J,KALYANARAMAN H,MARATHE N,et al.Nitric oxide?As a mediator of estrogen effects in osteocytes[J].Vitam Horm,2014,96:247-263.
[30] RALSTON S H,TODD D,HELFRICH M H,et al.Human osteoblast-like cells produce nitric oxide and expressinducible nitric oxide synthase[J].Endocrinology,1994,135(1):330-336.
[31] MACPHERSON H,NOBLE B S,RALSTON S H.Expression and functional role of nitric oxide synthase isoforms in human osteoblast-like cells[J].Bone,1999,24(3):179-185.
[32] ARMOUR K E,ARMOUR K J,GALLAGHER M E,et al.Defective bone formation and anabolic responses to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide sythase[J].Endocrinology,2001,142(2):760-766.
[33] SUH K S,RHEE S Y,KIM Y S,et al.Protective effect of liquiritigenin against methylglyoxal cytotoxicity in osteoblastic MC3T3-E1 cells[J].Food Funct,2014,5(7):1432-1440.
[34] NEVZATI E,SHAFIGHI M,BAKHTIAN K D,et al.Estrogen induces nitric oxide production via nitric oxide synthase activation in endothelial cells[J].Acta Neurochir Suppl,2015,120:141-145.
[35] AILHAUD G,MICHIELS J F,HEYMANN D,et al.Oxytocin reverses ovariectomy-induced osteopenia and body fat gain[J].Endocrinology,2014,155(4):1340-1352.
[36] RUSSELL K S,HAYNES M P,SINHA D,et al.Human vascular endothelial cells contain membrane binding sites for estradiol,which mediate rapid intracellular signaling[J].Proc Natl Acad Sci USA,2000,97(11):5930-5935.
[37] MENDELSOHN M E,KARAS R H.Rapid progress for non-nuclear estrogen receptor signaling[J].J Clin Invest,2010,120(7):2277-2279.
[38] GRASSI F,FAN X,RAHNNERT J,et al.Bone remodeling is moredynamic in the endothelial nitric oxide synthase mouse[J].Endocrinology,2006,147(9):4392-4399.
[39] WIMALAWANSA S J,DE MARCO G,GANGULA P,et al.Nitric oxide donor alleviates ovariectomy-induced bone loss[J].Bone,1996,18(4):301-304.
[40] HUKKANEN M,PLATTS L A,LAWES T,et al.Effect of nitric oxide donor nitroglycerin on bone mineral density in a rat model of estrogen deficiency-induced osteopenia[J].Bone,2003,32(2):142-149.
[41] REJNMARK L,VESTERGAARD P,MOSEKILDE L.Decreased fracture risk in users of organic nitrates:a nationwide case-control study[J].J Bone Miner Res,2006,21(11):1811-1817.
[42] JAMAL S A,HAMILTON C J,EASTELL R,et al.Effect of nitroglycerin ointment on bone density and strength in postmenopausal women:a randomized trial[J].JAMA,2011,305(8):800-807.
[43] MARATHE N,RANGASWAMI H,ZHUANG S,et al.Prosurvival effects of 17β-estradiol on osteocytes are mediated by nitric oxide/cGMP via differential actions of cGMP-dependent protein kinases Ⅰ and Ⅱ[J].J Biol Chem,2012,287(2):978-988.
[44] RANGASWAMI H,SCHWAPPACHER R,MARATHE N,et al.Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts[J].Sci Signal,2010,3(153):ra91.
[45] MANCINI L,MORADI-BIDHENDI N,BECHERINI L,et al.The biphasic effects of nitric oxide in primary rat osteoblasts are cGMP dependent[J].Biochem Biophys Res Commun,2000,274(2):477,481.
[46] HAGIWARA H,INOUE A,YAMAGUCHI A,et al.cGMP produced in response to ANP and CNP regulates proliferation and differentiation of osteoblastic cells[J].Am J Physiol,1996,270(5 Pt 1):C1311-C1318.
[47] WIMALAWANSA S J,GRIMES J P,WILSON A C,et al.Transdermal nitroglycerin therapy may not prevent early postmenopausal bone loss[J].J Clin Endocrinol Metab,2009,94(9):3356-3364.

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更新日期/Last Update: 2016-06-05