[1]张美霞,王丽娜,王秀娟,等.氟西汀联合舒肝解郁胶囊治疗伴有失眠的抑郁症疗效及安全性观察[J].新乡医学院学报,2016,33(6):489-491.[doi:10.7683/xxyxyxb.2016.06.012]
　ZHANG Mei-xia,WANG Li-na,WANG Xiu-juan,et al.Effectiveness of fluoxetine combined with Shuganjieyu capsule on depressed patients with insomnia[J].Journal of Xinxiang Medical University,2016,33(6):489-491.[doi:10.7683/xxyxyxb.2016.06.012]
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氟西汀联合舒肝解郁胶囊治疗伴有失眠的抑郁症疗效及安全性观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年6
页码:
489-491
栏目:
临床研究
出版日期:
2016-06-05

文章信息/Info

Title:
Effectiveness of fluoxetine combined with Shuganjieyu capsule on depressed patients with insomnia
作者:
张美霞; 王丽娜; 王秀娟; 孙欠欠; 王长虹
（新乡医学院第二附属医院早期干预一科，河南　新乡　543002）
Author(s):
ZHANG Mei-xia; WANG Li-na; WANG Xiu-juan; SUN Qian-qian; WANG Chang-hong
（Department of Early Itervention No.1，the Second Affiliated Hospital of Xinxiang Medical University，Xinxiang 453002，Henan Province，China）
关键词:
氟西汀; 舒肝解郁胶囊; 抑郁症; 失眠
Keywords:
fluoxetine; Shuganjieyu capsule; depression; insomnia
分类号:
R749.4
DOI:
10.7683/xxyxyxb.2016.06.012
文献标志码:
A
摘要:
目的　探讨氟西汀联合舒肝解郁胶囊治疗伴有失眠症状的抑郁症患者的疗效及安全性。方法　选择轻-中度伴失眠的抑郁症患者58例，随机分为观察组和对照组，每组29例。观察组患者给予氟西汀分散片联合舒肝解郁胶囊治疗，对照组仅给予氟西汀分散片治疗，共6周。应用汉密尔顿抑郁量表（HAMD） 和匹兹堡睡眠质量指数（PSQI）评定2组患者疗效，不良反应量表（TESS）评价2组患者不良反应情况。结果　治疗6周末，观察组患者治疗有效率为93.1%（27/29），对照组患者治疗有效率为82.2%（24/29），2组比较差异有统计学意义（P<0.05）。治疗前2组患者HAMD评分比较差异无统计学意义（P>0.05），治疗2、4、6周时，观察组患者HAMD评分较对照组显著降低，减分率较对照组显著升高（P<0.05）。治疗前观察组和对照组患者PSQI评分差异无统计学意义（P>0.05），治疗2、4、6周时，观察组患者PSQI评分较对照组显著降低，减分率较对照组显著升高（P<0.05）。观察组不良反应发生率（27.6%）与对照组（31.0%）比较差异无统计学意义（P>0.05）。结论　与单用氟西汀相比，氟西汀联合舒肝解郁胶囊治疗伴有失眠的轻-中度抑郁症患者疗效更显著，起效更快，对失眠症状效果更好，且不增加不良反应发生率。
Abstract:
Objective　To investigate the effectiveness and side-effect of fluoxetine combined with Shuganjieyu capsule for depressed patients with insomnia.Methods　A total of 58 light to moderate depressed patients with insomnia were chosen and randomly divided into observation group and control group，with 29 cases in each group.The patients in observation group were treated with fluoxetine combined with Shuganjieyu capsule while the patients in control group were treated with fluoxetine only for 6 weeks.Hamilton depression rating scale （HAMD） and Pittsburgh sleep quality index （PSQI） were used to evaluate the curative effect of the patients in the two groups，and treatment emergent symptom scale （TESS） was used to evaluate adverse reactions of patients in the two groups.Results　After the treatment of 6 weeks，the effective rate in observation group was 93.1%，which was 82.2% in control group，and there was significant difference between the two groups （P<0.05）.The HAMD score between the two groups before treatment had no significant difference （P>0.05），and the HAMD score decreased while the deducted rate increased significantly compared with control group after the treatment for 2，4 and 6 weeks （P<0.05）.Before treatment，there was no significant difference of PSQI score between research group and control group （P>0.05）.The PSQI score decreased while the deducted rate increased significantly compared with control group after the treatment for 2，4 and 6 weeks （P<0.05）.The incidence of adverse reactions was 27.6% in observation group and 31.0% in control group，respectively.There was no significant difference between the two groups （P>0.05）.Conclusion　Fluoxetine combined with Shuganjieyu capsule on mild-to-moderate depressed patients with insomnia has more apparent，work faster and better effect on insomnia than fluoxetine，and hasn′t increase the risk of adverse reactions.

参考文献/References:

［1］　谷景阳，詹和琴，韩金红，等.抑郁症患者脑白质变化研究进展［J］.新乡医学院学报，2015，32（1）：81-84.
［2］　石志红，石志福，王志勇.抑郁症的国内外研究进展［J］.中国民族医药杂志，2014，20（4）：58-61.
［3］　RIHMER Z，DME P，GONDA X.30 years against suicide：a summary of our research on depression and suicide prevention between 1985 and 2015［J］.Neuropsychopharmacol Hung，2015，17（3）：113-119.
［4］　张宝霞.镇静催眠药使用现状［J］.天津药学，2014，26（6）：67-70.
［5］　高磊.氟西汀联合舒肝解郁胶囊治疗脑卒中后抑郁症46例［J］.齐齐哈尔医学院学报，2012，33（9）：1177-1178.
［6］　世界卫生组织.ICD-10精神与行为障碍分类［M］.北京：人民卫生出版社，1993：97-103.
［7］　周仲英.中医内科学［M］.北京：中国中医药出版社，2003：392-395.
［8］　汤毓华.心理卫生评定量表手册［M］.增订版.中国心理卫生杂志社，1999：220-223.
［9］　慈书平，张希龙，杨宇，等.睡眠与睡眠疾病［M］.北京：军事医学科学出版社，2005：531-579.
［10］　曹森.抑郁症中医辨证分型与汉密尔顿抑郁量表的相关性研究［D］.成都：成都中医药大学，2009.
［11］　刘让东.腺点金丝桃化学成分的研究［D］.北京：北京协和医学院，2014.
［12］　郭冷秋，郭壮丽，康施瑶，等.刺五加总苷对REM睡眠剥夺所致大鼠记忆获得障碍的改善作用及其 LTP机制［J］.中国实验方剂学杂志，2012，20（13）：125-129.
［13］　FU J，ZHANG Y，WU R，et al.Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression［J］.Neural Regen Res，2014，9（5）：489-497.
［14］　傅锦华.新型抗抑郁中药舒肝解郁胶囊对抑郁模型大鼠的作用机制研究［D］.长沙：中南大学，2014.
［15］　KOU M J，CHEN J X.Integrated traditional and Western medicine for treatment of depression based on syndrome differentiation：a meta-analysis of randomized controlled trials based on the Hamilton depression scale［J］.J Tradit Chin Med，2012，32（1）：1-5.
［16］　郑琳，王丽萍，张顺，等.舒肝解郁胶囊联合氟西汀治疗抑郁症34例临床观察［J］.河北中医，2012，34（12）：1819-1821.

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更新日期/Last Update: 2016-06-05