[1]黄锦,张雪儿,李苑硕,等.轻度认知障碍与肠道微生物群的相关性研究进展[J].新乡医学院学报,2024,(4):383-387.[doi:10.7683/xxyxyxb.2024.04.016]
　HUANG Jin,ZHANG Xueer,LI Yuanshuo,et al.Research progress on the correlation between mild cognitive impairment and gut microbiota[J].Journal of Xinxiang Medical University,2024,(4):383-387.[doi:10.7683/xxyxyxb.2024.04.016]
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轻度认知障碍与肠道微生物群的相关性研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
期数:
2024年4
页码:
383-387
栏目:
综述
出版日期:
2024-04-05

文章信息/Info

Title:
Research progress on the correlation between mild cognitive impairment and gut microbiota
作者:
黄锦1; 2; 张雪儿1; 2; 李苑硕1; 2; 顿玲露2; 安红伟2; 卢昌均2
(1.广西中医药大学研究生院，广西　南宁　530000；2.柳州市中医医院神经内科，广西　柳州　545000）
Author(s):
HUANG Jin1; 2; ZHANG Xueer1; 2; LI Yuanshuo1; 2; DUN Linglu2; AN Hongwei2; LU Changjun2
(1.Graduate School of Guangxi University of Traditional Chinese Medicine,Nanning 530000,Guangxi Zhuang Autonomous Region,China;2.Neurology Department,Liuzhou Traditional Chinese Medical Hospital,Liuzhou 545000,Guangxi Zhuang Autonomous Region,China)
关键词:
轻度认知障碍; 肠道微生物群; 脑肠轴; 中医; 作用机制
Keywords:
mild cognitive impairment; gut microbiota; brain-gut axis; Chinese medicine; mechanisms of action
分类号:
R74
DOI:
10.7683/xxyxyxb.2024.04.016
文献标志码:
A
摘要:
轻度认知障碍（MCI）是正常衰老至痴呆发展中的一种认知损伤症候群。近几年老年人认知损伤发病率越来越高，已成为当今社会老年人的严重问题。肠道微生物群（GM）在MCI的发展中起重要作用，可影响大脑的行动及认知能力，促进MCI的发生发展过程；此外，GM还与不同类型的MCI具有相关性。本文从认知功能下降与GM失调的相关性、不同类型MCI与GM失调的关系、GM影响MCI的相关机制、中医药干预GM改善认知障碍等方面综述GM在MCI发生发展中的作用，分析GM是否可成为MCI预防、治疗的新靶点，以期为临床防治MCI提供参考。
Abstract:
Mild cognitive impairment (MCI) is a cognitive impairment syndrome that occurs from normal aging to dementia.In recent years,the incidence of cognitive impairment in the elderly has become higher and higher,which has become a serious problem for the elderly in today′s society.Studies suggest that gut microbiota (GM) plays an important role in the development of MCI,which can affect the brain′s action and cognitive ability,and then promote the occurrence and development of MCI.In addition,gut microbiota is also associated with different types of MCI.Therefore,this paper reviews the influence of gut microbiota in the occurrence and development of MCI from four aspects:the correlation between cognitive decline and intestinal dysbacteriosis,the relationship between different types of mild cognitive impairment and intestinal dysbacteriosis,the relevant mechanism of gut microbiota affecting mild cognitive impairment,and the intervention of traditional Chinese medicine in improving cognitive impairment of gut microbiota,and analyzes whether gut microbiota can become a new target for the prevention and treatment of MCI,in order to bring inspiration for the clinical prevention and treatment of mild cognitive impairment.

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更新日期/Last Update: 2024-04-05