[1]陈金玲,冯元元,饶珺.血清C-反应蛋白与白蛋白比值对卵巢癌患者腹腔热灌注联合静脉化疗后短期预后的预测价值[J].新乡医学院学报,2024,(4):338-342.[doi:10.7683/xxyxyxb.2024.04.007]
　CHEN Jinling,FENG Yuanyuan,RAO Jun.Effect of serum C-reactive protein-to-albumin ratio on short-term prognosis of ovarian cancer patients after intraperitoneal hyperthermia combined with intravenous chemotherapy[J].Journal of Xinxiang Medical University,2024,(4):338-342.[doi:10.7683/xxyxyxb.2024.04.007]
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血清C-反应蛋白与白蛋白比值对卵巢癌患者腹腔热灌注联合静脉化疗后短期预后的预测价值
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
期数:
2024年4
页码:
338-342
栏目:
临床研究
出版日期:
2024-04-05

文章信息/Info

Title:
Effect of serum C-reactive protein-to-albumin ratio on short-term prognosis of ovarian cancer patients after intraperitoneal hyperthermia combined with intravenous chemotherapy
作者:
陈金玲; 冯元元; 饶珺
（信阳市中心医院妇产科,河南　信阳　464000）
Author(s):
CHEN Jinling; FENG Yuanyuan; RAO Jun
(Department of Obstetrics and Gynecology,Xinyang Central Hospital,Xinyang 464000,Henan Province,China)
关键词:
卵巢癌; 腹腔热灌注化疗; 静脉化疗; C-反应蛋白; 白蛋白; C-反应蛋白与白蛋白比值; 预后
Keywords:
ovarian cancer; intraperitoneal hyperthermia; intravenous chemotherapy; C-reactive protein; albumin; C-reactive protein-to-albumin ratio; prognosis
分类号:
R737.31
DOI:
10.7683/xxyxyxb.2024.04.007
文献标志码:
A
摘要:
目的　分析血清C-反应蛋白与白蛋白比值对卵巢癌患者腹腔热灌注联合静脉化疗后短期预后的预测价值。
方法　选择2020年6月至2022年6月信阳市中心医院收治的120例行肿瘤细胞减灭术治疗的卵巢癌患者为研究对象，患者均采用腹腔热灌注联合静脉化疗，治疗3个周期后依据治疗效果将患者分为预后不良组（n=36）和预后良好组（n=78），比较2组患者治疗前血清C-反应蛋白、白蛋白水平及C-反应蛋白与白蛋白比值，采用Point-biserial相关分析评估血清C-反应蛋白与白蛋白比值与腹腔热灌注联合静脉化疗后卵巢癌患者短期预后的关系，受试者操作特征（ROC）曲线分析C-反应蛋白与白蛋白比值对腹腔热灌注联合静脉化疗后卵巢癌患者短期预后的预测价值。
方法　120 例卵巢癌术后患者中，114例完成3个周期的规范治疗。预后不良患者血清C-反应蛋白、C-反应蛋白与白蛋白比值高于预后良好患者，白蛋白水平低于预后良好患者（P<0.05）。相关性分析显示，血清C-反应蛋白、C-反应蛋白与白蛋白比值与卵巢癌患者术后短期预后呈正相关（P<0.05），血清白蛋白与患者短期预后呈负相关（P<0.05）。ROC曲线显示，血清C-反应蛋白、白蛋白、C-反应蛋白与白蛋白比值预测卵巢癌患者术后腹腔热灌注联合静脉化疗短期预后的敏感度分别为69.40%、89.70%、80.60%，特异度分别为89.70%、77.80%、92.30%，曲线下面积分别为0.776、0.795、0.845。
结论　血清C-反应蛋白、白蛋白、C-反应蛋白与白蛋白比值对腹腔热灌注联合静脉化疗后卵巢癌患者短期预后均具有一定的预测价值，C-反应蛋白与白蛋白比值预测价值较高。
Abstract:
Objective　To analyze the predictive value of serum C-reactive protein-to-albumin ratio (CAR) on the short-term prognosis of patients with ovarian cancer undergoing intraperitoneal hyperthermia combined with intravenous chemotherapy.
Methods　A total of 120 patients with ovarian cancer who underwent cytoreductive surgery in Xinyang Central Hospital from June 2020 to June 2022 were selected as the research subjects.All patients were treated with intraperitoneal hyperthermia combined with intravenous chemotherapy.After 3 cycles of treatment,patients were divided into the poor prognosis group (n=36) and the good prognosis group (n=78) based on the treatment effect.The serum C-reactive protein (CRP) and albumin levels and the CAR before treatment were compared between the two groups.Point-biserial correlation analysis was used to evaluate the relationship between the CAR and the short-term prognosis of ovarian cancer patients after intraperitoneal hyperthermia combined with intravenous chemotherapy.The receiver operating characteristic (ROC) curve was used to analyze the predictive value of the CAR on the short-term prognosis of ovarian cancer patients after intraperitoneal hyperthermia combined with intravenous chemotherapy.
Results　Of the 120 patients with ovarian cancer included in this study,114 completed 3 cycles of standardized treatment.Patients with poor prognosis had higher serum CRP and CAR and lower albumin level than those with good prognosis (P<0.05).Correlation analysis showed that serum CRP and CAR were positively correlated with the short-term prognosis of ovarian cancer patients (P<0.05),and serum albumin was negatively correlated with the short-term prognosis of patients (P<0.05).The ROC curve showed that the sensitivity of serum CRP,albumin and CAR in predicting the short-term prognosis of ovarian cancer patients after intraperitoneal hyperthermia combined with intravenous chemotherapy was 69.40%,89.70% and 80.60%,respectively,and the specificity was 89.70%,77.80% and 92.30%,respectively.The area under the curve was 0.776,0.795 and 0.845,respectively.
Conclusion　Serum CRP,albumin,and CAR have a certain predictive value for the short-term prognosis of ovarian cancer patients after intraperitoneal hyperthermia combined with intravenous chemotherapy,and CAR has a higher predictive value.

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更新日期/Last Update: 2024-04-05