[1]杨莹莹,王宏茹,王丽芳,等.热休克蛋白70在肿瘤中的作用研究进展[J].新乡医学院学报,2022,39(9):883-887.[doi:10.7683/xxyxyxb.2022.09.018]
　YANG Yingying,WANG Hongru,WANG Lifang,et al.Research progress on the role of heat shock protein 70 in tumor[J].Journal of Xinxiang Medical University,2022,39(9):883-887.[doi:10.7683/xxyxyxb.2022.09.018]
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热休克蛋白70在肿瘤中的作用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年9
页码:
883-887
栏目:
综述
出版日期:
2022-09-05

文章信息/Info

Title:
Research progress on the role of heat shock protein 70 in tumor
作者:
杨莹莹1; 王宏茹2; 王丽芳1; 张　瑜3; 任　峰3
（1.新乡医学院护理学院，河南　新乡　453003；2.新乡市第一人民医院护理部，河南　新乡　453000；3.新乡医学院基础医学院，河南　新乡　453003)
Author(s):
YANG Yingying1; WANG Hongru2; WANG Lifang1; ZHANG Yu3; REN Feng3
（1.School of Nursing,Xinxiang Medical University,Xinxiang 453003,Henan Province,China；2.Department of Nursing,Xinxiang First People′s Hospital,Xinxiang 453000,Henan Province,China;3.School of Basic Medical Sciences,Xinxiang Medical University,Xinxiang 453003,Henan Province,China）
关键词:
热休克蛋白70; 肿瘤; 靶向治疗
Keywords:
heat shock protein 70; tumor; targeted therapy
分类号:
R735.7
DOI:
10.7683/xxyxyxb.2022.09.018
文献标志码:
A
摘要:
热休克蛋白(HSP)是一类广泛存在于生物体中、具有高度保守性的蛋白。当细胞受到外界不利因素刺激时可诱导HSP的产生，其对维持应激状态下细胞内环境的稳定具有重要意义。HSP70在肿瘤细胞中表达升高，与肿瘤的发生、发展及转移密切相关。本文就HSP70的结构和功能及其在肿瘤发生、发展及靶向治疗中的作用等方面的研究进展进行综述。
Abstract:
Heat shock proteins (HSP) are a class of highly conserved proteins,which widely exist in organisms.HSP can be induced when cells are stimulated by external adverse factors,which is of great significance to maintain the stability of the intracellular environment under stress.The expression of HSP70 increases in tumor cells,and it is closely related to the occurrence,development and metastasis of tumor.This article reviews the research progress on the structure and function of HSP70,the role of HSP70 in occurrence and development of tumor and its application in targeted therapy for tumor.

参考文献/References:

［1］　YUN C W,KIM H J,LIM J H,et al.Heat shock proteins:agents of cancer development and therapeutic targets in anti-cancer therapy［J］.Cells,2019,9(1):60.
［2］　CHATTERJEE S,BURN T F.Targeting heat shock proteins in cancer:a promising therapeutic approach［J］.Int J Mol Sci,2017,18(9):1978.
［3］　MURPHY M E.The HSP70 family and cancer［J］.Carcinogenesis,2013,34(6):1181-1188.
［4］　ALBAKOVA Z,ARMEEV G A,KANEVSKIY L M,et al.HSP70 multi-functionality in cancer［J］.Cells,2020,9(3):587.
［5］　ZUIDERWEG E R,HIGHTOWER L E,GESTWICKI J E.The remarkable multivalency of the Hsp70 chaperones［J］.Cell Stress Chaperones,2017,22(2):173-189.
［6］　ROSENZWEIG R,NILLEGODA N B,MAYER M P,et al.The Hsp70 chaperone network［J］.Nat Rev Mol Cell Biol,2019,20(11):665-680.
［7］　GAO Y,HAN C,HUANG H,et al.Heat shock protein 70 together with its co-chaperone CHIP inhibits TNF-alpha induced apoptosis by promoting proteasomal degradation of apoptosis signal-regulating kinase1［J］.Apoptosis,2010,15(7):822-833.
［8］　GABAI V L,MABUCHI K,MOSSER D D,et al.Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis［J］.Mol Cell Biol,2002,22 (10):3415-3424.
［9］　STANKIEWICZ A R,LACHAPELLE G,FOO C P,et al.Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing bax translocation［J］.J Biol Chem,2005,280 (46):38729-38739.
［10］　BEERE H M,WOLF B B,CAIN K,et al.Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome［J］.Nat Cell Biol,2000,2(8):469- 475.
［11］　GUO F,SIGUA C,BALI P,et al.Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells［J］.Blood,2005,105(3):1246-1255.
［12］　ZHANG Y,LUO W,WANG Y,et al.Enhanced antitumor immunity of nanoliposome- encapsulated heat shock protein 70 peptide complex derived from dendritic tumor fusion cells［J］.Oncol Rep,2015,33 (6):2695-2702.
［13］　VOSTAKOLAEI M A,MOLAVI O,HEJAZI M S,et al.Isolation and characterization of a novel scFv antibody fragments specific for Hsp70 as a tumor biomarker［J］.J Cell Biochem,2019,120 (9):14711-14724.
［14］　KAMPINGA H H,HAGEMAN J,VOS M J,et al.Guidelines for the nomenclature of the human heat shock proteins［J］.Cell Stress Chaperones,2009,14(1):105-111.
［15］　YOSHIDOMI K,MURAKAMI A,YAKABE K,et al.Heat shock protein 70 is involved in malignant behaviors and chemosensitivities to cisplatin in cervical squamous cell carcinoma cells［J］.J Obstet Gynaecol Res,2014,40(5):1188-1196.
［16］　BONVINI P,ZORZI E,MUSSOLIN L,et al.Consequences of heat shock protein 72 (Hsp72) expression and activity on stress-induced apoptosis in CD30+ NPM-ALK+ anaplastic large-cell lymphomas［J］.Leukemia,2012,26(6):1375-1382.
［17］　SAMPSON J,O′REGAN L,DYER M J S,et al.Hsp72 and Nek6 cooperate to cluster amplified centrosomes in cancer cells［J］.Cancer Res,2017,77(18):4785-4796.
［18］　YANG Z,ZHUANG L,SZATMARY P,et al.Upregulation of heat shock proteins (HSPA12A,HSP90B1,HSPA4,HSPA5 and HSPA6) in tumor tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma［J］.Int J Med Sci,2015,12(3):256-263.
［19］　COURT K A,HATAKEYAMA H,WU S Y,et al.HSP70 inhibition synergistically enhances the effects of magnetic fluid hyperthermia in ovarian cancer［J］.Mol Cancer Ther,2017,16(5)： 966-976.
［20］　BONAM S R,RUFF M,MULLER S.HSPA8/HSC70 in immune disorders:a molecular rheostat that adjusts chaperone-mediated autophagy substrates［J］.Cells,2019,8(8):849.
［21］　TANAKA M,MUN S,HARADA A,et al.Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions［J］.PLoS One,2014,9(5):e96785.
［22］　SUN G,CAO Y,DAI X,et al.Hsc70 interacts with β4GalT5 to regulate the growth of gliomas［J］.Neuromolecular Med,2019,21 (1):33-41.
［23］　SUN G,CAO Y,XU Y,et al.Overexpression of Hsc70 promotes proliferation,migration,and invasion of human glioma cells［J］.J Cell Biochem,2019,120(6):10707-10714.
［24］　WADHWA R,YAGUCHI T,HASAN M K,et al.Hsp70 family member,mot-2/mthsp70/GRP75,binds to the cytoplasmic sequestration domain of the p53 protein［J］.Exp Cell Res,2002,274 (2):246-253.
［25］　YUN C O,BHARGAVA P,NA Y,et al.Relevance of mortalin to cancer cell stemness and cancer therapy［J］.Sci Rep,2017,7:42016.
［26］　HU Y,YANG L,YANG Y,et al.Oncogenic role of mortalin contributes to ovarian tumorigenesis by activating the MAPK-ERK pathway［J］.J Cell Mol Med,2016,20(11):2111-2121.
［27］　STARENKI D,SOSONKIN A N,HONG S K,et al.Mortalin (GRP75/HSPA9) promotes survival and proliferation of thyroid carcinoma cells［J］.Int J Mol Sci,2019,20(9):2069.
［28］　NA Y,KAUL S C,RYU J,et al.Stress chaperone mortalin contributes to epithelial- mesenchymal transition and cancer metastasis［J］.Cancer Res,2016,76(9):2754-2765.
［29］　LU G,LUO H,ZHU X.Targeting the GRP78 pathway for cancer therapy［J］.Front Med (Lausanne),2020,7:351.
［30］　ZIELINSKA H A,DALY C S,ALGHAMDI A,et al.Interaction between GRP78 and IGFBP-3 affects tumourigenesis and prognosis in breast cancer patients［J］.Cancers(Basel),2020,12 (12):3821.
［31］　LEE J H,YOON Y M,LEE S H.GRP78 regulates apoptosis,cell survival and proliferation in 5-fluorouracil-resistant SNUC5 colon cancer cells［J］.Anticancer Res,2017,37(9):4943-4951.
［32］　VOSTAKOLAEI M A,HATAMI-BAROOGH L,BABAEI G,et al.Hsp70 in cancer:a double agent in the battle between survival and death［J］.J Cell Physiol,2021,236(5):3420-3444.
［33］　SAKAI K,INOUE M,MKAMI S,et al.Functional inhibition of heat shock protein 70 by VER-155008 suppresses pleural mesothelioma cell proliferation via an autophagy mechanism［J］.Thorac Cancer,2021,12(4):491-503.
［34］　XU M,JIN T,CHEN L,et al.Mortalin is a distinct biomarker and prognostic factor in serous ovarian carcinoma［J］.Gene,2019,696:63-71.
［35］　SCHILLING D,GARRIDO C,COMBS S E,et al.The Hsp70 inhibiting peptide aptamer A17 potentiates radiosensitization of tumor cells by Hsp90 inhibition［J］.Cancer Lett,2017,390:146- 152.
［36］　LEU J I,PIMKINA J,PANDEY P,et al.HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells［J］.Mol Cancer Res,2011,9(7):936-947.
［37］　ZHOU Y,MA J,ZHANG J,et al.Pifithrin-μ is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70［J］.Oncol Rep,2017,37(1):313-322
［38］　SCHMITT E,MAINGRET L,PUIG P E,et al.Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma［J］.Cancer Res,2006,66(8):4191-4197.
［39］　GOLOUDINA A R,DEMIDOV O N,GARRIDO C.Inhibition of HSP70:a challenging anti-cancer strategy［J］.Cancer Lett,2012,325 (2):117-124.
［40］　YAGLOM J A,WANG Y,LI A,et al.Cancer cell responses to Hsp70 inhibitor JG-98:comparison with Hsp90 inhibitors and finding synergistic drug combinations［J］.Sci Rep,2018,8(1):3010.
［41］　DORARD C,DE THONRL A,COLLURA A,et al.Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis［J］.Nat Med,2011,17 (10):1283-1289.

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更新日期/Last Update: 2022-09-05