[1]罗雅琴,黄　伟.细胞自噬在免疫性血小板减少症中的作用机制研究进展[J].新乡医学院学报,2022,39(4):381-386.[doi:10.7683/xxyxyxb.2022.04.017]
　LUO Yaqin,HUANG Wei.Research progress on the mechanism of autophagy in immune thrombocytopenia[J].Journal of Xinxiang Medical University,2022,39(4):381-386.[doi:10.7683/xxyxyxb.2022.04.017]
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细胞自噬在免疫性血小板减少症中的作用机制研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年4
页码:
381-386
栏目:
综述
出版日期:
2022-04-05

文章信息/Info

Title:
Research progress on the mechanism of autophagy in immune thrombocytopenia
作者:
罗雅琴1; 黄　伟2; 3
(1.山东中医药大学附属医院，山东　济南　250014；2.山东省中医药研究院，山东　济南　250014；3.齐鲁工业大学/山东省科学院山东省分析测试中心，山东　济南　250014)
Author(s):
LUO Yaqin1; HUANG Wei2; 3
(1.The Affiliated Hospital of Shandong University of Chinese Medicine,Jinan 250014,Shandong Province,China;2.Shandong Academy of Chinese Medicine，Jinan 250014,Shandong Province,China;3.Shandong Analysis and Test Center,Qilu University of Technology/Shandong Academy of Sciences,Jinan 250014,Shandong Province,China)
关键词:
免疫性血小板减少症; 细胞自噬; 发病机制
Keywords:
immune thrombocytopenia; autophagy; pathogenesis
分类号:
R558+.2
DOI:
10.7683/xxyxyxb.2022.04.017
文献标志码:
A
摘要:
细胞自噬是一种自我消化现象，广泛存在于细胞生命活动中，在细胞生理或病理过程中起重要作用。自噬不足和自噬过度都会导致机体发生病变，包括多种自身免疫性疾病。研究发现，细胞自噬参与T、B淋巴细胞的激活和增殖以及B细胞存活的机制。免疫性血小板减少症（ITP）是一种常见的自身免疫介导的出血性疾病，血小板膜蛋白刺激免疫系统产生抗体，最终导致血小板减少，而T、B淋巴细胞免疫失衡及巨核细胞功能障碍是ITP发生的主要机制。本文对细胞自噬在ITP中的作用机制进行综述，以期为探索ITP的新型自噬靶向治疗药物提供参考。
Abstract:
Autophagy is a self-digestion phenomenon,which is widely present in cell life activities and plays an important role in cell physiology or pathology.Insufficient and excessive autophagy can lead to pathological changes in the body,including a variety of autoimmune diseases.Studies have found that autophagy is involved in the activation and proliferation of T and B lymphocytes and the mechanism of the survival of B cells.Immune thrombocytopenia (ITP) is a common autoimmune-mediated bleeding disease,platelet membrane proteins can stimulate the immune system to produce antibodies,and ultimately lead to thrombocytopenia;while the immune imbalance of T and B lymphocytes and megakaryocyte dysfunction are the main mechanisms of ITP.This article reviews the mechanism of autophagy in ITP,hoping to provide a reference for exploring new autophagy targeted therapy drugs for ITP.

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更新日期/Last Update: 2022-04-05